Rejuran S is the scar-specific formulation of the polynucleotide family — a thicker, more viscous preparation of DNA-fragment biostimulant, injected directly beneath depressed acne scars. Where lasers remodel by controlled injury, polynucleotides work the repair side: supporting the regeneration environment so remodelling scars rebuild with better-quality tissue. It is a supporting actor with growing evidence — and it is at its best inside a programme, not instead of one.
WhatsApp Dr Sin Yong →Both carry the same active family — polynucleotides, purified DNA fragments whose regenerative signalling has been studied for years in wound healing [1]. The difference is formulation and job description. Rejuran Healer (the version on the Rejuran facial page) is a lighter preparation distributed through the dermis for overall skin quality. Rejuran S is the scar specialist: thicker, more cohesive, and placed focally beneath a depressed scar, where its viscosity gives mild immediate support while its biology goes to work on the scar bed's repair environment.
The polynucleotide literature has matured from tradition to trials: systematic reviews of randomised studies support PN/PDRN across skin regeneration, healing support and scar-adjacent indications, with a consistent safety profile [1,2]. The honest reading for acne scars specifically: PN is a legitimate biological adjunct with supportive evidence, not a structural monotherapy — a depressed scar tethered by fibrous bands still needs the tether released, and a deep ice pick still needs CROSS. Where PN earns its place is quality: treated scar beds heal from energy sessions with better-conditioned tissue, which is exactly the job a supporting biological should do.
In Dr Sin Yong's sequencing, Rejuran S slots between and after the structural moves: after subcision releases a rolling scar, PN supports the released bed; between Tetra Pro fractional sessions, it feeds the remodelling the laser initiated; under stubborn depressed scars, it adds biological pressure where energy alone plateaus. Scar-type mapping (see the scar guide) decides where it earns its cost — and where it would be an expensive way to avoid the treatment the scar actually needs.
PN as a solo fix for structural scars — biology cannot un-tether a band or fill a well. Judging it like filler — polynucleotides are biostimulants; the change is gradual tissue-quality improvement, not instant volume. Endless standalone sessions without a programme — the adjunct logic only pays inside a sequence. And brand worship in either direction — the molecule family has evidence; the plan around it is what delivers.
“Polynucleotides improve the terrain a scar heals on — but no biology un-tethers a band or fills a well, which is why Rejuran S belongs inside a programme, not instead of one.”
— Dr Sin Yong
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Same polynucleotide family, different formulation and job: Healer spreads through the dermis for skin quality; S is thicker and placed focally beneath scars.
Courses of a few sessions weeks apart are typical, planned around the energy treatments it supports. The response is cumulative, like all biostimulants.
Injections under scar tissue sting briefly; numbing cream and technique keep it very tolerable. Expect small raised blebs that settle within a day or so.
The PN/PDRN literature reports a consistent safety profile across trials — it is a well-tolerated biological. Screening at assessment covers the exceptions.
Depressed structural scars need structural treatment; PN improves the healing terrain around those moves. Anyone selling it as a standalone scar cure is overselling the molecule.
Usually mapped together — energy initiates remodelling, PN supports it. Sequence depends on your scar census, set at assessment.