Profhilo is a high-concentration hyaluronic acid that spreads through the skin to support its quality, not to add volume or lift. For Profhilo in Singapore, Dr Sin Yong uses a modified BAP: the defined points as the safety framework, then placement where the face shape needs it, including scarred skin.
Profhilo Singapore in brief: Profhilo is a concentrated hyaluronic acid injected into the skin at set points to improve skin quality: dryness, crepiness and early laxity. It is not a filler, so it adds no volume and does not lift. In Chinese it is often called 逆时针.
Dr Sin Yong · MBBS (NUS) · MRCS (Edin) · MSc Aesthetic Medicine with Distinction (Queen Mary, London) · MSc Practical Dermatology (Cardiff) · Global Key Opinion Leader
Profhilo is a stabilised hybrid cooperative complex of high- and low-molecular-weight hyaluronic acid, injected at defined anatomical points to act on the skin itself rather than to add volume — assessed and placed by Dr Sin Yong at the clinic on Orchard Road, Singapore.
Profhilo Singapore · Dr Sin Yong, Orchard Road
Not a filler. A remodeller for crepey skin.
Five-point BAP technique
Face and neck
No added volume
Doctor-injected
Illustrative, not a patient. Every treatment is performed by Dr Sin Yong after an in-person assessment.
Profhilo's high-concentration hyaluronic acid spreads through the skin to improve hydration and laxity without adding volume. Dr Sin Yong uses it on the face and neck where the skin has gone crepey, and explains when a skin booster or filler suits better.
Crepey, loose skin suits Profhilo; hollowing does not, and is discussed separately.
five points per sidePlace
The BAP technique lets the product spread across the skin from a few entry points.
after the pairReview
Two sessions a month apart, then reviewed before any maintenance is planned.
Suitability is decided at an in-person assessment. No prices are quoted on this page; fees are given in writing after the assessment. Images and video are illustrative, not patients.
At a glance
Profhilo in Singapore is a stabilised hybrid cooperative complex of high- and low-molecular-weight hyaluronic acid, made by IBSA and injected at defined points to act on the skin itself. It is bio-remodelling, not a dermal filler, so it adds no volume or projection.
Also called: bio-remodelling hyaluronic acid, 逆时针, プロファイロ
Key takeaways
Profhilo is an injectable of uncrosslinked hyaluronic acid in a hybrid complex, used for bio-remodelling, not volume.
It is considered for skin quality concerns such as crepiness, dullness and fine surface lines, including the neck and hands.
It adds no projection or structure, so it does not correct a hollow cheek, flat bridge or receded chin.
It is placed at defined Bio Aesthetic Points; Dr Sin Yong adds placement by face shape and treats scarred skin.
Dr Sin Yong, an aesthetic physician, assesses and performs it, and it is separate from Profhilo Structura.
Profhilo Structura (IBSA) is a separate product from Profhilo: hyaluronic acid formulated to be placed in the superficial fat compartments of the lateral face, where the manufacturer positions it for adipose tissue restructuring rather than skin remodelling.
How it differs from Profhilo
Profhilo is placed intradermally at the BAP points for skin quality. Structura is placed deeper, in the subcutaneous fat, at a different set of points, in a two-session protocol per the manufacturer.
Who it is considered for
Early lateral-face hollowing or loss of fat-compartment support where a conventional filler would be too much. It is not a lifting treatment and does not replace lost bone support.
A stabilised hybrid cooperative complex (NAHYCO) of high- and low-molecular-weight hyaluronic acid, manufactured by IBSA
Composition
32 mg of high-molecular-weight HA and 32 mg of low-molecular-weight HA in a 2 mL syringe
Crosslinking
None. The two HA weights are stabilised thermally rather than with a chemical crosslinker such as BDDE
Category
Bio-remodelling, not volumising. It is not a dermal filler and is not a mesotherapy cocktail
Injection pattern
Bio Aesthetic Points (BAP): a defined set of points per side, chosen for vascular safety and for spread through the subcutaneous plane
Target tissue
Fibroblasts in the dermis, rather than a tissue plane that holds shape
What it does not do
It adds no projection and holds no structure, so it does not correct a hollow cheek, a flat bridge or a receded chin
Related formulation
Profhilo Structura is a separate IBSA product aimed at structural support, not the same product as Profhilo
Technique used here
A modified BAP: the defined Bio Aesthetic Points kept as the safety framework, with additional placement according to the individual face shape, and treatment of scarred skin alongside
Profhilo is an injectable preparation of hyaluronic acid, but it belongs to a different category from the hyaluronic acid fillers most people have heard of. It contains two populations of hyaluronic acid — one of high molecular weight, one of low — combined into what the manufacturer calls a hybrid cooperative complex, under the trade name NAHYCO. A 2 mL syringe carries 32 mg of each.
The distinction that matters clinically is the absence of a chemical crosslinker. Conventional hyaluronic acid fillers are crosslinked, usually with BDDE, so that the gel resists degradation and holds a shape under the skin. That is what allows a filler to project a chin or support a cheek. Profhilo is stabilised by a thermal process instead, and holds no shape at all. Injected, it spreads.
Illustrative. Profhilo is an uncrosslinked hyaluronic acid preparation — a fluid, not a gel that holds shape.
So the two products answer different questions. A filler answers where is volume missing. Profhilo answers how is this skin behaving.
Why it is not a filler, and why that matters
This is the single most common misunderstanding, and it is worth being blunt about, because it is the reason people come away unimpressed.
If the complaint is a flat midface, a receded chin or a deep nasolabial fold driven by volume loss, Profhilo will not address it. Those are structural problems and they need something that holds structure — a crosslinked filler, or in some cases a different approach entirely. Profhilo placed into that situation will not produce the change the patient came for, and no amount of it will.
Where it is the right tool is the opposite situation: skin that has lost quality rather than volume. Crepiness. A dull, thin, poorly hydrated surface. Fine lines that sit on the skin rather than in the underlying shape. Necks and the backs of hands, where there is little to volumise and a great deal of surface change.
A sensible consultation separates those two things before anything is injected. Volume restoration and bio-remodelling are not competing options; they answer different complaints, and a face often needs the first before the second is worth doing.
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“Profhilo is not a filler. It gives improvement to areas by giving hydration, nutrients, and elements that the skin likes.”
Dr Sin YongOn what bio-remodelling actually does
A modified BAP — how Dr Sin Yong places it
The manufacturer's protocol specifies a fixed set of Bio Aesthetic Points per side. As a default it is sound: the positions are chosen for vascular safety and for predictable spread, and they are the right starting point for anyone working without a detailed assessment of the face in front of them.
Dr Sin Yong treats that set as the safety framework rather than the whole plan. A fixed pattern treats every face as the same face, and faces are not the same. Where the midface has deflated, where the jawline has softened, where the asymmetry sits — those regions place the greatest mechanical demand on the skin, and they do not always coincide with the standard points.
So the technique he uses keeps the defined points and adds placement according to the shape of the individual face. The anatomical rules governing where an injectable may safely sit do not change. What changes is the map.
He also places it into scarred skin, which the standard protocol does not address. Scar tissue is organised differently from the skin around it and behaves differently, and treating it alongside the rest of the face is a deliberate part of the plan rather than an afterthought.
This is the part that does not transfer from a brochure. It is also why the same product, in different hands, is not the same treatment. The standard points, and what the modified pattern keeps and adds, are set out in the Profhilo BAP technique.
What the published evidence actually shows
The laboratory work behind the product is reasonably well characterised, and it is worth separating what has been measured from what is claimed in marketing.
The foundational study, published in PLoS ONE in 2016, examined hybrid cooperative complexes against the individual hyaluronic acid weights in skin cell models. Two findings are relevant. First, durability: roughly 35% of the high-molecular-weight material remained after ten days of exposure to hyaluronidase, against under 10% for standard high-molecular-weight hyaluronic acid on its own. Second, cellular response: the complexes increased gene expression of collagen types I, III, IV and VII and of elastin relative to the individual components, with type III collagen expression in fibroblasts rising roughly twelve-fold.
Those are laboratory measurements of gene expression in cell models. They explain the proposed mechanism; they are not a statement of what any individual's skin will do. There is also an open-label study in Asian patients, which is the more relevant population for Singapore, and a body of review literature on hybrid cooperative complexes in aesthetic medicine. All are listed in the references below.
Profhilo in Singapore: which product for which skin
Profhilo in Singapore is often asked for by name when the skin actually needs something else. Four injectables are compared in clinic because they are confused with one another: Profhilo, Profhilo Structura, Rejuran and Juvelook. They are placed in different layers and are directed at different skin. The table sets out what each is, where it goes, the skin it tends to suit, and what it does not do, so that the request can be matched to the finding rather than to the brand.
Profhilo treats the skin, not the shape. If the face needs a contour, it needs something else.— Dr Sin Yong
Poly-D,L-lactic acid (PDLLA) microspheres carried in non-cross-linked hyaluronic acid (VAIM)
The dermis and just beneath it, where the PDLLA prompts collagen over months
Skin that needs both hydration on the day and a gradual collagen response: fine lines, enlarged pores and shallow acne scars
Act as a volumising filler; the PDLLA cannot be dissolved with hyaluronidase
How the choice is made
The first question is what the skin lacks. Skin that is thirsty and has lost bounce, with no real volume loss, is the Profhilo pattern. Skin that is damaged, red or textured points to Rejuran rather than Profhilo, because polynucleotides are repair signalling rather than hydration. A face whose sides have flattened because the superficial fat has changed is assessed for Profhilo Structura, which is a different product in a different layer. Where fine lines sit over shallow scars or open pores and a slow collagen response is wanted, Juvelook is considered, with the caveat that its PDLLA component is not reversible.
None of the four adds projection. A hollow cheek, a flat bridge or a receded chin is a volume question and is directed to dermal fillers or a collagen biostimulator, not to a skin injectable. Dr Sin Yong assesses the skin and the underlying support before any of these is chosen, and more than one may be staged where the skin shows more than one problem.
Profhilo vs Profhilo Structura vs other skin boosters
Product or class
What it is
Where it is placed
Directed at
What it does not do
Profhilo
Uncrosslinked hybrid hyaluronic acid (32 mg high- and 32 mg low-molecular-weight in 2 mL), thermally stabilised, made by IBSA
The skin, from defined Bio Aesthetic Points on each side
Crepey texture, hydration and early fine lines
Add volume, hold a contour or lift
Profhilo Structura
A separate IBSA product: 90 mg of hybrid hyaluronic acid in 2 mL
Superficial fat compartments of the lateral face, placed by cannula
Fat-compartment change in the lateral cheek and preauricular area
Replace filler for defined volume loss, lift heavy descent or remove skin
Hyaluronic acid skin boosters, such as Restylane Skinboosters
Soft, lightly stabilised or non-crosslinked hyaluronic acid
Many small injections into the dermis
Dull, dehydrated skin with fine surface lines
Restore volume, lift or treat pigment
Polynucleotides, such as Rejuran
Purified DNA fragments, usually from salmon
The dermis
Repair of texture, fine lines and thin under-eye skin
Add volume or lift; a fish allergy is raised first
A resorbable scaffold that prompts the body's own collagen
Deeper planes, according to the product
Broader volume loss and firmness over a longer arc
Change surface hydration, or be dissolved with hyaluronidase
Who it suits, who should wait, who is referred on
Tends to suit
Crepey, dull or thin skin with poor hydration
Fine surface lines that sit on the skin rather than in the underlying shape
Neck and backs of the hands where there is little to volumise
Skin with scarring that is being treated alongside the rest of the face
Better to wait
Pregnancy or breastfeeding
Active infection, inflammation or a cold sore at the injection sites
A goal that depends on projection, such as a flat bridge or a receded chin
Referred on
Volume loss or a deep fold driven by structure → filler or other structural assessment
Marked skin excess or descent → surgical assessment
Who should not have this treatment
Known allergy to hyaluronic acid or any component of the product
Active infection, inflammation or skin disease at the injection sites
Pregnancy or breastfeeding
Active autoimmune condition, until assessed
Bleeding disorder or blood-thinning medicine, considered individually
History of severe allergic reaction, considered individually
People hoping to correct volume loss, a flat midface or a receded chin tend to respond poorly, because Profhilo is a skin quality treatment and the wrong tool for structure.
Profhilo does not tighten skin in the way an energy-based device does. If the complaint is jowling or a loose jawline, the relevant category is focused ultrasound (see HIFU) or monopolar radiofrequency (see the VF Lift – Vertical Facelift). A good deal of disappointment with injectables has one cause. The layer that is easiest to reach gets treated, rather than the layer that is causing the complaint.
The indication is skin quality — texture, hydration and light reflectance — rather than lost volume.
Who should not have Profhilo?
Profhilo is not injected in anyone with a known allergy to hyaluronic acid or to any component of the product. It is deferred where there is active infection, inflammation, a cold sore or an acne flare at the injection points, and in pregnancy and while breastfeeding, where it has not been studied.
Other conditions call for caution rather than a refusal: autoimmune disease, a history of severe allergic reactions, a tendency to keloid scarring, and a bleeding tendency or blood-thinning medicines, which make bruising more likely. Where unknown or non-dissolvable filler has been placed in the area before, what is already in the tissue is established first, because layering over it complicates any later correction.
Profhilo is also the wrong choice for anyone whose main concern is volume loss, descent or a loose jawline, for the reasons set out above, and for anyone expecting a lift. Medical history and current medicines are reviewed, and suitability is decided at consultation.
Is Profhilo worth it? Who it suits and who it disappoints
Whether Profhilo is worth it depends on what you hope it will change, and that is a question about the problem rather than the product. It is considered for skin whose surface quality has changed while the underlying shape has not: crepey texture, dullness, loss of hydration and early fine lines, including on the neck and hands. People who understand that it acts on the skin itself, and that it is a doctor-assessed injectable plan, are the ones for whom the decision makes sense. Cost follows the plan and is set out in writing at consultation, after assessment, so there is no figure to quote here.
It disappoints when the expectation is something it was never built to do. It adds no volume or projection, so a hollow cheek, a flat bridge or a receded chin is not its territory. It does not tighten skin the way an energy-based treatment does, so jowling and a loose jawline are better assessed for lifting with the VF Lift – Vertical Facelift or Time Freeze Laser LCLR®. It does not treat pigment or change pore size, and because hyaluronic acid is broken down by hyaluronidase it is not a lifelong intervention. An examination before injection separates skin quality from volume and from descent, and sometimes the honest advice is that Profhilo is not the right first step.
Before you book
Declare any allergy to hyaluronic acid or previous reaction to injectables
Tell us about pregnancy, breastfeeding, cold sores and any autoimmune condition
Mention blood thinners, aspirin, fish oil or supplements that increase bruising
Avoid fresh sun exposure and pause strong skincare actives as advised
Bring photos, a list of previous injectables and records of earlier treatments
Questions to ask before Profhilo in Singapore
These questions help you understand what would be placed, where and why, before anything is injected.
Who examines my skin, and who performs the injections?
Is Profhilo or Profhilo Structura proposed, where would it be placed, and why?
What can Profhilo not do for volume loss or sagging?
What are the risks for me, including allergy to any component?
What aftercare is advised, and how do I reach the doctor if a lump appears?
Which alternatives, such as another skin booster or no treatment, were considered?
What determines the fee
The fee depends on the areas treated, such as face, neck or hands, and the syringes needed to cover them. It also depends on whether placement goes beyond the standard points to suit your face shape, and whether it is combined with another treatment such as a filler. The plan is set after assessment. A written quote is given at consultation. The consultation also decides whether Profhilo is advised at all, or whether a filler or a different approach would suit your concern better.
It is an uncrosslinked hyaluronic acid preparation that spreads, adds no projection and answers skin quality rather than shape.
“Profhilo and Profhilo Structura are the same product.”
Structura is a separate IBSA product aimed at structural support, so the two are assessed and chosen differently.
Profhilo, skin boosters, Profhilo Structura and fillers: which does what?
These four are often quoted as if they were interchangeable, and they are not. The useful way to separate them is by the job each is built to do and by whether it is designed to spread or to stay put. Profhilo and hyaluronic acid skin boosters are directed at the quality of the skin. Profhilo Structura is a separate product, placed deeper in the lateral fat compartments. A dermal filler is cross-linked so that it holds a shape. The table sets them side by side. If you have been quoted for any of these by name alone, ask which product it is, where it is placed and what it is meant to change, because the answers decide what the treatment can and cannot do.
Profhilo compared with skin boosters, Profhilo Structura and dermal fillers
Option
Built to
Spreads or stays put
Where it is placed
What it does not do
Profhilo
Act on the skin itself, using a stabilised hybrid hyaluronic acid complex
Spreads through the tissue from each point
The skin, from defined Bio Aesthetic Points
Add volume, hold a contour or lift
Hyaluronic acid skin boosters
Hydrate the dermis with lightly stabilised or non-crosslinked hyaluronic acid
Hydrates where it is placed
Many small injections into the dermis
Restore volume, lift or treat pigment
Profhilo Structura
Address change in the fat compartments of the lateral face
Placed by cannula as a separate product
Superficial fat compartments of the lateral face
Replace filler where defined volume is needed
Dermal filler (cross-linked hyaluronic acid)
Add volume or hold a contour
Stays where placed, built to resist spread
Planes chosen by the area being treated
Act on skin quality as its main job
Not sure skin quality is the right concern to treat? See which treatment fits which cause, a one-page guide to ten common concerns.
1. MessageWhatsApp +65 8023 7170 with what is bothering you. A reply comes from the clinic, not a bot.
2. AssessmentDr Sin Yong examines you himself on Orchard Road, with ultrasound where earlier filler is involved.
3. A plan in writingWhat he would do, what he would not, the fee factors, and the option of no treatment.
Every treatment is performed by Dr Sin Yong personally. Singapore Medical Council registered · invited to share his clinical expertise internationally as a Key Opinion Leader for CLASSYS, DEKA, HIRONIC, FOTONA, ALMA, LUTRONIC and ILOODA · HSA-registered devices · ultrasound-guided correction
Profhilo is an uncrosslinked hyaluronic acid preparation that spreads through the skin to address its quality; it is not a filler and adds no volume or lift. It suits crepey, dull or thin skin, including the neck and the backs of the hands, rather than hollows or sagging. Dr Sin Yong uses a modified BAP: the standard points as the safety framework, then placement where the face needs it. Profhilo Structura is a separate product, placed deeper. The fee depends on the areas and syringes needed.
Profhilo: sessions, downtime and how long it lasts
Profhilo Singapore at a glance
How many sessions
Two sessions one month apart, then one session every 6 months.
Downtime
Small bumps at the five points for a few hours; occasional bruising.
How long it lasts
About 6 months per course.
Figures are typical ranges from Dr Sin Yong's practice and the published literature; your plan, including the number of sessions, is set after the assessment and may differ. Fees are given in writing after the assessment: see how we quote.
Profhilo Singapore — Frequently Asked Questions
How many Profhilo sessions do I need?+
There is no fixed number, and none is promised here. The plan follows your skin: how crepey or thin it is, the areas treated, and how the skin responds after the first treatment. Dr Sin Yong reviews before any further session and decides from what the skin has actually done, not from a standard protocol. Some skins also need a different product alongside, such as a polynucleotide for texture or lifting for laxity.
When will I see Profhilo results?+
The small blebs at each injection point settle first, and the gel spreads through the skin as it does. Any change in hydration and crepiness then builds gradually as the skin responds, and it varies between people. No date can be promised. Dr Sin Yong reviews the skin once it has had time to respond, before deciding whether anything further would help.
Can Profhilo be used on the neck?+
Yes, where the concern is crepey or thin skin on the neck, and also on the backs of the hands. Profhilo acts on skin quality; it does not tighten a loose neck or soften muscle bands. For neck laxity, Dr Sin Yong uses the VF Lift – Vertical Facelift and Time Freeze Laser LCLR®, and where the neck shows both problems, the order of treatment is planned at the assessment.
Is Profhilo registered with HSA?+
Yes. Profhilo, made by IBSA Farmaceutici Italia, is registered with Singapore’s Health Sciences Authority as an injectable medical device. You can check any injectable on HSA’s medical device register, and check that the clinic holds an MOH licence.
Can Profhilo lumps be dissolved?+
Yes, a Profhilo lump can be dissolved with hyaluronidase, because Profhilo is hyaluronic acid, provided the lump is the Profhilo itself. Dr Sin Yong scans the lump first, because filler or another product placed earlier can sit in the same area. Before any planned dissolving he checks your allergy history and always does a skin test, then places a small first dose into the mapped lump and reviews it at about 48 hours. A lump that is red, hot or tender needs a doctor the same day (A&E if no doctor can see you today) and is treated medically first.
Is Profhilo a filler?+
No. Profhilo is a hyaluronic acid product, but it is not crosslinked and it holds no shape under the skin. A dermal filler is crosslinked precisely so that it resists spreading and can project or support a feature. Profhilo spreads through the subcutaneous plane by design. It will not correct a hollow cheek, a flat nasal bridge or a receded chin, and it is not a substitute for a filler where volume is what is missing.
What is the difference between Profhilo and Profhilo Structura?+
They are separate products from the same manufacturer, IBSA. Standard Profhilo is directed at skin quality through bio-remodelling. Structura carries more hyaluronic acid and is placed by cannula into the superficial fat compartments of the lateral face, where it is directed at fat-compartment change; it is still not a conventional crosslinked filler. If a clinic has quoted you for “Profhilo” without specifying which, ask.
How long does Profhilo last?+
Hyaluronic acid, crosslinked or not, is broken down by hyaluronidase in the tissue. The laboratory work shows the hybrid complex resists that degradation better than high-molecular-weight hyaluronic acid alone, but it is still degraded. This is not a lifelong change, and the skin resumes its own trajectory once the material has gone. Any specific duration quoted to you should be treated as an average across a study population, not a prediction for your skin.
What are the side effects?+
Small raised deposits at the injection points immediately after treatment are expected rather than a complication, because the product is placed as discrete boluses. Bruising, tenderness and transient swelling are common to any injectable. The serious risks are the vascular ones that attend any product placed near facial vessels, which is why the injection points are defined and why who injects matters more than what is injected.
How much does Profhilo cost in Singapore?+
The cost depends on the areas treated, how many syringes your plan needs, whether placement goes beyond the standard points to suit your face, and whether Profhilo is combined with another treatment. A written quote is given at consultation after assessment, and the consultation also decides whether Profhilo is advised for your concern at all.
Is Profhilo worth it?+
It can be worthwhile for skin that has lost quality, such as crepey, dull or thin skin, including the neck and hands. It is not worth choosing for volume loss, a flat midface, a receded chin or a deep fold driven by structure, because it adds no projection. Assessment separates the two before anything is injected.
What are the disadvantages of Profhilo?+
It adds no volume or structure, so it will not correct hollows or recession. Small bumps, tenderness and bruising at the injection points are expected, and less common complications include lumps, infection and allergic reaction. Results depend on skin condition and technique, and more than one visit may be advised.
Does Profhilo hurt?+
Profhilo can sting more than many injections because the gel is concentrated, but the feeling is brief at each point, and only a small number of points are used. Numbing cream can be applied first. Tell Dr Sin Yong at any point if it is uncomfortable, and the pace is adjusted.
Is Profhilo claimable under MediSave or insurance?+
No. Treatment for appearance is not claimable under MediSave or MediShield Life, and most private insurance plans exclude it. If you have a question about your own policy, check with your insurer before booking.
Is Profhilo the same as 逆时针?+
Yes. 逆时针 (literally “anti-clockwise injection”) is a Chinese nickname for Profhilo. The name is marketing shorthand and does not describe a result.
Profhilo Singapore clinics offer is not a filler: it is a high-concentration hyaluronic acid that spreads through the skin to improve hydration and laxity rather than adding volume. Dr Sin Yong uses it for crepey skin on the face and neck and explains when a skin booster or filler suits better.
Stellavato A, Corsuto L, D'Agostino A, et al. Hyaluronan hybrid cooperative complexes as a novel frontier for cellular bioprocesses re-activation. PLoS ONE 2016. source Efficacy and tolerability of stable hybrid cooperative complexes of high- and low-molecular weight hyaluronic acid in Asian patients: an open-label study. source Hybrid cooperative complexes of low- and high-molecular-weight hyaluronic acid in aesthetic medicine. source Health Sciences Authority. Infosearch — register of health products and medical devices approved for supply in Singapore. source Singapore Medical Council. Guidelines on Aesthetic Practices for Doctors, 2016 Edition. source
Efficacy, safety, and tolerance of a new injection technique for high- and low-molecular-weight hyaluronic acid hybrid complexes (Laurino C, Palmieri B, Coacci A). Eplasty, 2015. www.hmpgloballearningnetwork.com
Efficacy and tolerance of an injectable medical device containing stable hybrid cooperative complexes of high- and low-molecular-weight hyaluronic acid: a monocentric 16 weeks open-label evaluation (Sparavigna A, Tenconi B). Clinical, Cosmetic and Investigational Dermatology, 2016. www.dovepress.com
Hybrid cooperative complexes of low- and high-molecular-weight hyaluronic acid in aesthetic medicine: a review including the Bio Aesthetic Points (BAP) technique (Tintor G, et al.). Pharmaceuticals (MDPI), 2026. www.mdpi.com
Listing of Registered Medical Devices (Singapore Medical Device Register), Health Sciences Authority. data.gov.sg, 2026. data.gov.sg
Medically reviewed by Dr Sin Yong, MBBS (NUS), MRCS (Edinburgh) · Last updated 5 November 2026 · Editorial policy
Related reading
Profhilo vs Rejuran: An Honest Comparison — Profhilo versus Rejuran compared honestly — hybrid hyaluronic acid versus polynucleotides, hydration-and-laxity versus r…
Where Dr Sin Yong consults: Orchard Road, Singapore (unit on booking) · Orchard MRT · Mon–Fri 10am–8pm, Sat 11am–3pm · WhatsApp +65 8023 7170 · Getting here · How fees are quoted
