Medically reviewed by Dr Sin Yong · Last reviewed · 8 min read · Jump to questions
See also: what sets a skin booster fee.
Published 20 October 2026 · Reviewed by Dr Sin Yong

The Chanel injection is a nickname, used in parts of Asia, for NCTF 135HA: a non-cross-linked hyaluronic acid skin booster combined with vitamins, amino acids, minerals, coenzymes and nucleic acids, made by the French laboratory Fillmed. It has no connection with the fashion house, and the name says nothing about what it does. This article explains the ingredients, how it differs from Profhilo and Rejuran, and what to ask.
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The Chanel injection is worth decoding before you book: asked for the product name, a clinic should answer NCTF 135HA by Fillmed. It is a hydrating hyaluronic acid booster given as many superficial micro-injections, so it adds no volume, does not lift and does not clear pigment. Profhilo and Rejuran are different products for different skin problems, not substitutes for it.
The Chanel injection is NCTF 135HA, a skin booster made by Fillmed Laboratoires in France, a company previously known under the Filorga name. The nickname seems to have attached itself because the product arrives in a glass vial and is sold as a luxury treatment; it has nothing to do with the fashion house and tells you nothing about the ingredients, the mechanism or the evidence. In Singapore you will also see it written as the 'Chanel booster', 'Chanel skin booster' or 'Chanel mesotherapy'. The product behind every one of those names is the same.

The useful habit, with any skin booster that has acquired a nickname, is to translate the name back into its category: what the material is, where it is placed and what it is meant to do. That translation is what the skin booster treatment page does for every class, and the skin booster brands guide does for the brand names. This article does it for one nickname.
NCTF stands for New Cellular Treatment Factor. The '135' refers to the number of ingredients the manufacturer lists, and 'HA' to hyaluronic acid. The formulation combines non-cross-linked hyaluronic acid with a polycomponent mixture of vitamins, amino acids, minerals, coenzymes, nucleic acids and antioxidants.
Because the hyaluronic acid is non-cross-linked, it does not hold a shape or occupy space the way a dermal filler does; it hydrates the dermis and is broken down. The rationale for the other ingredients is that ageing fibroblasts may work better when supplied with the substrates they use. A review of polycomponent mesotherapy formulations of this kind describes that rationale and laboratory findings in fibroblast cultures. Laboratory findings explain the idea behind a product; they are not a prediction of what an individual's skin will do.
| Component | What it is | What it is there for, according to the manufacturer's rationale |
|---|---|---|
| Hyaluronic acid (non-cross-linked) | A water-binding sugar molecule | Hydration of the dermis; it adds no volume |
| Vitamins | Including vitamins of the B group, C and E | Co-factors in collagen synthesis and antioxidant activity |
| Amino acids | Building blocks of proteins | Substrates for fibroblasts |
| Minerals and coenzymes | Trace elements and enzyme helpers | Support for cell metabolism |
| Nucleic acids | DNA and RNA building blocks | Support for cell turnover |
How it is delivered matters as much as what is in it. NCTF 135HA is placed by many fine, superficial micro-injections into the upper dermis, or by a needling technique, in the manner of mesotherapy. Small raised points, redness and occasional bruising are expected afterwards and settle on their own.
“A nickname tells me what the clinic wants the treatment to sound like. The vial tells me what is going into the skin. I read the vial.”
Dr Sin YongOn Chanel injection
All three are called skin boosters, and none of them is a filler. Beyond that they are different materials with different mechanisms, placed differently, and chosen for different skin.

| NCTF 135HA ('Chanel injection') | Profhilo | Rejuran | |
|---|---|---|---|
| Material | Non-cross-linked HA plus vitamins, amino acids, minerals, coenzymes, nucleic acids | Hybrid complex of high- and low-molecular-weight HA, thermally stabilised without BDDE | Polynucleotides purified from salmon DNA |
| Maker | Fillmed, France | IBSA, Italy | PharmaResearch, Korea |
| Class | Hydrating hyaluronic acid booster, polycomponent | Bio-remodelling hyaluronic acid | Polynucleotide booster |
| How it is placed | Many superficial micro-injections across the area | A few defined Bio Aesthetic Points; Dr Sin Yong uses a modified BAP pattern | Intradermal micro-injections |
| Directed at | Dull, dehydrated skin and fine surface lines | Early loss of firmness and crepey skin, including neck and hands | Thin, fragile skin, texture and post-acne skin quality |
| Not for | Hollows, descent, pigment | Hollows, descent, pigment | Fish allergy; hollows, descent, pigment |
The practical difference is what the skin is short of. Dehydration and dullness point towards a hyaluronic acid booster, of which NCTF 135HA is one multi-ingredient example. Skin that has started to soften without descending points towards Profhilo. Thin skin that needs repair rather than water points towards a polynucleotide such as Rejuran. The Profhilo vs Rejuran guide compares those two in more depth. None of the three fills a hollow, lifts a jowl or clears pigment, and a face whose main concern is one of those is assessed for something else.
Injectable skin boosters placed into the skin are regulated in Singapore by the Health Sciences Authority (HSA) as medical devices or therapeutic products, depending on how the product is classified. Whether a specific product is registered, and under what name, can be checked on the HSA's online register, or the clinic can be asked to confirm it. The nickname will not appear on any register; the product name and the manufacturer will. A doctor should be able to tell you exactly what is being injected, show you the vial, and record the product and batch in your notes.
Two other rules sit behind every injectable in Singapore. Under the Singapore Medical Council's guidelines on aesthetic practice, injectables are performed by a registered doctor after a consultation, with consent taken in a way that leaves time to consider. And under the medical advertising rules, a clinic cannot promise an outcome or advertise with before-and-after photographs, which is why a page like this describes a product and stops short of telling you what it will do for your skin.
Hyaluronic acid boosters are one of the classes used at this practice, chosen for dull, dehydrated skin with fine surface lines once the examination confirms that hydration is what the skin is short of. Whether a polycomponent booster such as NCTF 135HA, a plain hyaluronic acid booster, Profhilo, a polynucleotide or no injectable at all is proposed is decided at that examination, not by the name a patient arrives with. Dr Sin Yong examines the skin himself and performs every injection personally.

What a booster cannot do is weighed at the same visit. Hollows are assessed for filler, descent for lifting, pigment for a laser such as laser toning or pico laser, and tethered acne scars for subcision first. Where the skin is dull because of low-grade inflammation rather than dryness, an inflammation-directed laser may be weighed instead of, or before, any booster. The point of the consultation is to find the cause, because a booster given to skin that needed something else is a treatment that cannot work.
Aftercare for any skin booster is broadly similar: keep the area clean, avoid make-up over the injection points until they have closed, avoid heat, saunas and strenuous exercise for a short period, and protect the skin from the sun. Specific instructions are given on the day for the product used.
Every treatment is performed by Dr Sin Yong personally. Singapore Medical Council registered · invited to share his clinical expertise internationally for CLASSYS, DEKA, Fotona, Hironic and Ilooda.
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WhatsApp Dr Sin Yong →or use the enquiry formNo. It is a nickname for NCTF 135HA, a skin booster made by the French laboratory Fillmed, formerly Filorga. There is no connection with the fashion house. The name is marketing shorthand used in parts of Asia and says nothing about the ingredients, how it works or the evidence behind it.
No. It is a skin booster: non-cross-linked hyaluronic acid with vitamins, amino acids, minerals, coenzymes and nucleic acids, placed superficially to act on hydration and fine surface lines. It does not hold a shape, add volume or lift. A hollow cheek or a receded chin is a filler question, not a booster question.
They are different materials for different skin. NCTF 135HA is a hydrating multi-ingredient booster for dull, dehydrated skin; Profhilo is a hybrid hyaluronic acid placed at defined points for early loss of firmness. Which, if either, suits you is decided at examination of what the skin is short of, not by comparing names.
No. Rejuran is a polynucleotide purified from salmon DNA, directed at skin repair and texture, and it is avoided in anyone with a fish allergy. NCTF 135HA is hyaluronic acid with added vitamins and amino acids, directed at hydration. They work through different mechanisms and are not interchangeable.
Hyaluronic acid boosters are one of the classes used at this practice, and which product is proposed follows an in-person assessment. The consultation decides whether a hydrating booster, Profhilo, a polynucleotide, another treatment or no injectable suits your skin. Ask on WhatsApp if you have a specific product in mind; enquiries are answered in English and Chinese.
Small raised points where product was placed, redness and occasionally a bruise, which settle on their own. Keep the area clean, avoid make-up until the points have closed, and avoid heat and strenuous exercise for a short period. Lumps, spreading redness, pain or dusky skin should be reported promptly.
Polycomponent mesotherapy formulations for the treatment of skin aging and improvement of skin quality. Clinical, Cosmetic and Investigational Dermatology, 2015. source
An International Survey on the Use of a Polyrevitalizing Solution With or Without Other Aesthetic Procedures in Daily Practice. Journal of Cosmetic Dermatology, 2025. source
Injectable Non-Animal Stabilized Hyaluronic Acid as a Skin Quality Booster: An Expert Panel Consensus. Journal of Drugs in Dermatology, 2018. source
Guidelines on Aesthetic Practices for Doctors. Singapore Medical Council, 2016. source
Register of medical devices and therapeutic products (InfoSearch). Health Sciences Authority, Singapore, 2026. source
About this page: written and medically reviewed by Dr Sin Yong, MBBS (NUS), MRCS (Edinburgh) · Last reviewed 20 October 2026 · Illustrative images only, not patients · Editorial policy
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