Rejuran Healer in Singapore:
what is in the syringe, which skin it is for, and what a visit involves

What is Rejuran Healer, and what is in the syringe?

Rejuran Healer is a polynucleotide skin booster. The active material is long chains of nucleotides purified from salmon DNA, filtered and sterilised so that what is injected is the polymer and not genetic information. In Healer the concentration is approximately 20 mg/mL, which is why the product is often described as 2 per cent, and the chains span a molecular weight range of roughly 50 to 1,500 kDa. The preparation is a clear, viscous gel, thicker than a hyaluronic acid skin booster but thinner than a filler, and it has a slightly tacky feel that is familiar to anyone who has handled it.

Two terms get mixed up. PN denotes polynucleotide, the longer-chain material in the Rejuran range; PDRN denotes polydeoxyribonucleotide, shorter fragments of the same family used in other preparations. Products built on each are not the same product, a distinction set out on the PN vs PDRN guide.

It is not a filler. Nothing in the syringe is engineered to occupy space or hold a contour. Polynucleotides act on the repair environment of the dermis: an influence on fibroblast activity and matrix turnover, and signalling through adenosine A2A receptor pathways, which is also how the anti-inflammatory effect is described. What is being bought is a signal to the tissue, delivered where the tissue can act on it.

Which skin is Rejuran Healer for, and which is it not?

Healer is the whole-face preparation, and the complaints it is directed at are dermal-quality complaints: skin that has become thin, dull or crepey; fine lines that show at rest; elasticity that has slackened; and the texture left behind by acne once the active inflammation has settled. The appearance of enlarged pores belongs here too, not because anything shrinks a pore, which is a fixed opening, but because surface texture and dermal support decide how strongly a pore contrasts with the skin around it.

It is not for a hollow or a deficient contour, which is a structural problem needing material engineered to stay where it is put. It is not for melasma, sun-induced marks or post-inflammatory hyperpigmentation, which are chromophore problems addressed with light-based and topical approaches. It does not lift a jawline, and it does not release a tethered scar.

Who should wait, and who is referred on

• Fish allergy is asked about directly, because the material is fish-derived.
• Pregnancy and breastfeeding: treatment is deferred.
• Active infection, inflamed skin or active acne in the field: settled first.
• A tendency to keloid scarring is weighed where injection is near scarred tissue.
• Anyone expecting volume, a lift or pigment clearance is being offered the wrong treatment, and is told so.

“Rejuran Healer is a signal to the skin to repair, not a material that holds a shape. If what you want is a contour, I will say so and plan something else, because injecting the wrong thing well is still the wrong thing.”

Dr Sin YongOn Rejuran Healer polynucleotide injection

How does Rejuran Healer differ from Rejuran S and Rejuran I?

The three share the same polynucleotide; what changes is viscosity and therefore where the material can sensibly be placed. Healer is the mid-viscosity preparation spread across a field of skin. Rejuran S is thicker and is placed into and around scars rather than spread, as the skin-quality component of a wider acne scar plan. Rejuran I is thinner, for the fragile periorbital skin where a thicker gel would sit visibly.

Healer is also the preparation most people mean by a "Rejuran facial", a phrase that describes whole-face micro-injection by a doctor, not a facial in the spa sense. The owner page on Rejuran in Singapore explains the range in full and how it sits against Profhilo, hyaluronic acid boosters and biostimulators.

What does a Rejuran Healer visit involve?

The visit begins with examination, not with the syringe. Dr Sin Yong looks at the skin under good light and under stretch, sorts a post-acne face into its components, and decides whether the complaint is skin quality, which a polynucleotide addresses, or structure, which it does not. Fish allergy, pregnancy and keloid history are confirmed at the same time.

Topical anaesthetic is applied and left to take effect. The face is cleaned and the material is placed intradermally in a distributed pattern of micro-injections, by fine needle or by an injector device that deposits small volumes at a set depth; which is used depends on the area. The pattern is a grid of closely spaced points across the cheeks, temples, forehead and jawline, with the under-eye handled separately with the thinner preparation. Each point raises a small papule or wheal as the gel sits in the dermis. That is the expected appearance, not a complication, and it is the reason the visit is usually timed when nothing important follows the same evening.

Dr Sin Yong performs the injections himself after in-person assessment. He often pairs Healer with a resurfacing session or with RF microneedling, placing the repair signal where the skin has been asked to heal; whether and in what order is decided at review, not in advance.

What decides the plan?

Treatment is planned individually, so the plan follows the examination rather than a published package. The factors Dr Sin Yong weighs at consultation are:

• The area: the full face differs from a defined field of post-acne skin, and the periorbital area is a separate decision.
• Which preparation the findings indicate: Healer, S, I and HB are formulated differently and are not interchangeable.
• Whether skin quality is the whole complaint or one part of it, since a tethered scar needs subcision or resurfacing alongside and a hollow needs a different material.
• How the work is staged over time, and how the skin responded to the previous visit.
• Skin type and healing tendency, including the likelihood of bruising or post-inflammatory darkening in Fitzpatrick III to V skin.

A figure quoted before examination would not reflect the person's skin, which is why cost is set out at consultation and not on this page.

Aftercare and recovery after Rejuran Healer

The papules settle as the material is taken up, and the skin looks ordinary again as they do. Bruising is possible, more so where vessels are superficial, and fades on its own. For the first evening make-up, heat, alcohol and vigorous exercise are avoided and a cool compress eases swelling; after that a plain barrier-supporting routine is usually all that is asked for. The full day-by-day guidance is on the skin booster aftercare page.

What warrants prompt review rather than waiting: pain that increases instead of settling, spreading redness and warmth, swelling that does not subside, or a lump that persists once the papules have gone. Nodules can occur where material is deposited unevenly or too superficially, and infection is uncommon but possible with any needle through skin. Allergic reaction is rare, which is why fish allergy is asked about rather than assumed absent.

Any change in texture and hydration develops gradually rather than on the day; the early papules are not the result. The plan and any intervals are set at review.