Rejuran Healer Singapore: Rejuran Healer is the standard polynucleotide skin booster, purified from salmon DNA at roughly 20 mg/mL and injected into the dermis as a field of micro-injections for texture, fine lines, elasticity and post-acne skin. It adds no volume and does not lift. Dr Sin Yong assesses and injects it personally on Orchard Road, Singapore.
Where crepey skin needs hydration rather than repair, see Profhilo.
Published 20 October 2026 · Reviewed by Dr Sin Yong
Rejuran Healer is the standard facial preparation in the Rejuran range: polynucleotide purified from salmon DNA at roughly 20 mg/mL, injected into the dermis as a field of micro-injections across the face. It is directed at skin texture, fine lines and elasticity, and at the quality of post-acne skin. It adds no volume, does not lift and does not remove pigment. Dr Sin Yong assesses and injects it personally.
Rejuran Healer is the standard facial polynucleotide skin booster, purified from salmon DNA at about 20 mg/mL and injected into the dermis by a doctor. For Rejuran Healer in Singapore, Dr Sin Yong uses it for texture, fine lines and elasticity, not hollows or sagging, and checks fish allergy, pregnancy, infection and keloid tendency first.
What is Rejuran Healer, and what is in the syringe?
Rejuran Healer is a polynucleotide skin booster. The active material is long chains of nucleotides purified from salmon DNA, filtered and sterilised so that what is injected is the polymer and not genetic information. In Healer the concentration is approximately 20 mg/mL, which is why the product is often described as 2 per cent, and the chains span a molecular weight range of roughly 50 to 1,500 kDa. The preparation is a clear, viscous gel, thicker than a hyaluronic acid skin booster but thinner than a filler, and it has a slightly tacky feel that is familiar to anyone who has handled it.
Illustrative image — not a patient.
Two terms get mixed up. PN denotes polynucleotide, the longer-chain material in the Rejuran range; PDRN denotes polydeoxyribonucleotide, shorter fragments of the same family used in other preparations. Products built on each are not the same product, a distinction set out on the PN vs PDRN guide.
It is not a filler. Nothing in the syringe is engineered to occupy space or hold a contour. Polynucleotides act on the repair environment of the dermis: an influence on fibroblast activity and matrix turnover, and signalling through adenosine A2A receptor pathways, which is also how the anti-inflammatory effect is described. What is being bought is a signal to the tissue, delivered where the tissue can act on it. The clinical evidence is still building: a 2024 review of polynucleotides in aesthetic medicine found that some studies reported gains in skin elasticity and hydration while others found limited or no benefit, and called for further research.
Which skin is Rejuran Healer for, and which is it not?
Healer is the whole-face preparation, and the complaints it is directed at are dermal-quality complaints: skin that has become thin, dull or crepey; fine lines that show at rest; elasticity that has slackened; and the texture left behind by acne once the active inflammation has settled. The appearance of enlarged pores belongs here too, not because anything shrinks a pore, which is a fixed opening, but because surface texture and dermal support decide how strongly a pore contrasts with the skin around it.
Illustrative image — not a patient.
It is not for a hollow or a deficient contour, which is a structural problem needing material engineered to stay where it is put. It is not for melasma, sun-induced marks or post-inflammatory hyperpigmentation, which are chromophore problems addressed with light-based and topical approaches. It does not lift a jawline, and it does not release a tethered scar.
Who should wait, and who is referred on
Fish allergy is asked about directly, because the material is fish-derived.
Pregnancy and breastfeeding: treatment is deferred.
Active infection, inflamed skin or active acne in the field: settled first.
A tendency to keloid scarring is weighed where injection is near scarred tissue.
Anyone expecting volume, a lift or pigment clearance is being offered the wrong treatment, and is told so.
“Rejuran Healer is a signal to the skin to repair, not a material that holds a shape. If what you want is a contour, I will say so and plan something else, because injecting the wrong thing well is still the wrong thing.”
Dr Sin YongOn Rejuran Healer polynucleotide injection
How does Rejuran Healer differ from Rejuran S and Rejuran I?
The three share the same polynucleotide; what changes is viscosity and therefore where the material can sensibly be placed. Healer is the mid-viscosity preparation spread across a field of skin. Rejuran S is thicker and is placed into and around scars rather than spread, as the skin-quality component of a wider acne scar plan. Rejuran I is thinner, for the fragile periorbital skin where a thicker gel would sit visibly.
Preparation
Viscosity
Where it is placed
Directed at
Cannot do
Rejuran Healer
Mid
Intradermally across the face in a distributed pattern
Texture, fine lines, elasticity, post-acne skin quality
Add volume, lift, clear pigment
Rejuran S
High
Into and around scarred skin
The skin-quality component of acne scarring
Release a tethered scar or resurface a fixed-wall scar
Rejuran I
Low
Thin periorbital skin
Fine lines and crepey under-eye skin, once the cause is diagnosed
Correct hollowing, shadow or herniated fat
Rejuran HB
Mid, with hyaluronic acid
Intradermally
Skin needing both a repair signal and hydration
Replace a filler or a structural treatment
Healer is also the preparation most people mean by a "Rejuran facial", a phrase that describes whole-face micro-injection by a doctor, not a facial in the spa sense. The owner page on Rejuran in Singapore explains the range in full and how it sits against Profhilo, hyaluronic acid boosters and biostimulators.
What does a Rejuran Healer visit involve?
The visit begins with examination, not with the syringe. Dr Sin Yong looks at the skin under good light and under stretch, sorts a post-acne face into its components, and decides whether the complaint is skin quality, which a polynucleotide addresses, or structure, which it does not. Fish allergy, pregnancy and keloid history are confirmed at the same time.
Illustrative image — not a patient.
Topical anaesthetic is applied and left to take effect. The face is cleaned and the material is placed intradermally in a distributed pattern of micro-injections, by fine needle or by an injector device that deposits small volumes at a set depth; which is used depends on the area. The pattern is a grid of closely spaced points across the cheeks, temples, forehead and jawline, with the under-eye handled separately with the thinner preparation. Each point raises a small papule or wheal as the gel sits in the dermis. That is the expected appearance, not a complication, and it is the reason the visit is usually timed when nothing important follows the same evening.
Dr Sin Yong performs the injections himself after in-person assessment. He often pairs Healer with a resurfacing session or with RF microneedling, placing the repair signal where the skin has been asked to heal; whether and in what order is decided at review, not in advance.
How Dr Sin Yong does Rejuran Healer, step by step
Dr Sin Yong examines the skin under good light and under stretch, and sorts what is skin quality from what is structure.
Fish allergy, pregnancy, breastfeeding, active infection and keloid history are confirmed first.
Topical anaesthetic is applied and the face is cleaned.
He places the polynucleotide intradermally as a grid of micro-injections, by fine needle or injector device, himself, at the clinic on Orchard Road, Singapore; the under-eye is handled separately.
Whether to pair it with resurfacing or RF microneedling, and in what order, is decided at review.
Rejuran Healer, RF microneedling, or both?
Rejuran Healer is often compared with microneedling because both are used for texture and post-acne skin. They work differently, and in Dr Sin Yong’s plans they are more often combined than chosen between.
Rejuran Healer and RF microneedling compared
Rejuran Healer
RF microneedling
What it does
Places polynucleotide in the dermis to support repair
Creates controlled micro-injury and heat to prompt collagen remodelling
What it suits
Thin, dull or sensitised skin; fine texture; post-acne skin quality
Enlarged pores, shallow scarring and texture where remodelling is the aim
What it cannot do
Add volume, lift or release tethered scars
Fill a hollow or treat pigment on its own
Usual aftermath
Small raised points that settle over a day or so
Redness and pinpoint marks for a few days
How they combine
Often given after the energy-based step to support recovery
Often the first step, with Rejuran Healer planned around it
Which comes first, and how the sessions are spaced, is set at the assessment. Where scars are deep or tethered, subcision or laser is weighed as well; see the Rejuran Healer, S and I overview for the rest of the range.
What decides the plan?
Treatment is planned individually, so the plan follows the examination rather than a published package. The factors Dr Sin Yong weighs at consultation are:
The area: the full face differs from a defined field of post-acne skin, and the periorbital area is a separate decision.
Which preparation the findings indicate: Healer, S, I and HB are formulated differently and are not interchangeable.
Whether skin quality is the whole complaint or one part of it, since a tethered scar needs subcision or resurfacing alongside and a hollow needs a different material.
How the work is staged over time, and how the skin responded to the previous visit.
Skin type and healing tendency, including the likelihood of bruising or post-inflammatory darkening in Fitzpatrick III to V skin.
A figure quoted before examination would not reflect the person's skin, which is why cost is set out at consultation and not on this page.
More questions about Rejuran Healer in Singapore
Does Rejuran Healer help with pores?
Not directly. Rejuran Healer is directed at the repair environment of the dermis: texture, fine lines, elasticity and post-acne skin quality. It is not designed to change pore diameter, and enlarged pores often come from oil output, sun damage and laxity around the opening, which have their own treatments. Where pores are the main complaint, Dr Sin Yong looks at those causes first and may plan a laser or RF microneedling, with a polynucleotide as support where skin quality also needs it.
How many Rejuran Healer sessions do I need?
There is no fixed number, and no number is promised here. A course is planned from your skin at the first assessment, and each further session is decided from how the skin has responded, not from a package. Starting skin quality, the area, whether Healer is combined with laser or RF microneedling, and your own healing all change the plan. Dr Sin Yong reviews the skin before each repeat and stops when further sessions are unlikely to add anything.
Can Rejuran Healer be used on the neck?
It can, where the concern is skin quality: fine crepey lines, thin skin or uneven texture on the neck. The neck has thinner skin than the face, so the depth and spacing of the micro-injections are adjusted, and bruising is checked for. Rejuran Healer does not tighten loose skin or lift a sagging neck; for laxity, Dr Sin Yong uses the VF Lift – Vertical Facelift and Time Freeze Laser LCLR®, and plans the order if both problems are present.
Is Rejuran Healer the same as Rejuran HB?
No. Rejuran Healer carries polynucleotide on its own. Rejuran HB combines polynucleotide with hyaluronic acid in one syringe, adding a hydrating component to the repair signal. They are separate preparations in the same range, along with S for scarred skin and I for the under-eye area. Which one suits depends on whether the skin mainly needs repair, hydration, or both, and that is decided at the assessment, with the product name recorded in your notes.
Aftercare and recovery after Rejuran Healer
The papules settle as the material is taken up, and the skin looks ordinary again as they do. Bruising is possible, more so where vessels are superficial, and fades on its own. For the first evening make-up, heat, alcohol and vigorous exercise are avoided and a cool compress eases swelling; after that a plain barrier-supporting routine is usually all that is asked for. The full day-by-day guidance is on the skin booster aftercare page.
What warrants prompt review rather than waiting: pain that increases instead of settling, spreading redness and warmth, swelling that does not subside, or a lump that persists once the papules have gone. Nodules can occur where material is deposited unevenly or too superficially, and infection is uncommon but possible with any needle through skin. Allergic reaction is rare, which is why fish allergy is asked about rather than assumed absent.
Any change in texture and hydration develops gradually rather than on the day; the early papules are not the result. The plan and any intervals are set at review.
Your next step
1. MessageWhatsApp +65 8023 7170 with what is bothering you. A reply comes from the clinic, not a bot.
2. AssessmentDr Sin Yong examines you himself on Orchard Road, with ultrasound where earlier filler is involved.
3. A plan in writingWhat he would do, what he would not, the fee factors, and the option of no treatment.
Every treatment is performed by Dr Sin Yong personally. Singapore Medical Council registered · invited to share his clinical expertise internationally for CLASSYS, DEKA, Fotona, Hironic and Ilooda.
Skin boosters versus moisturisers. A moisturiser sits on your skin. This is a different conversation at a different depth. Topicals work at the surface, exactly where they're meant to. Treatments that place hydrating or stimulating agents into the dermis are addressing a different layer entirely. Neither replaces the other. If anyone tells you one makes the other unnecessary, ask more questions.
Transcript of Dr Sin Yong's video, lightly edited for reading.
Related on this site
What the days after treatment look like is set out under Rejuran downtime.
It depends on the area and the skin. The face is usually planned around one syringe of Rejuran Healer; the neck usually takes another, and a wide field of post-acne skin may need more. Dr Sin Yong decides the amount at the examination rather than by a set package, and the under-eye is planned separately with Rejuran I. The amount used is written in your notes.
Yes, where the concern is skin quality. Men often ask about texture, enlarged pores and post-acne skin, and Rejuran Healer is weighed for these in the same way as for women. Male skin is often thicker, which can change the depth and the amount used. Pores and scarring are often planned with RF microneedling or laser as well, and that sequence is decided at the assessment.
How long the effect of Rejuran Healer lasts is not fixed, and no duration can be promised. It depends on age, skin type, sun exposure, smoking, the condition of the skin at the start and whether other treatments are in the same plan. Polynucleotides work through the skin’s own repair response, which varies between people, so the interval between visits is set at review rather than quoted in advance.
Rejuran Healer is used for the skin-quality part of post-acne skin, such as uneven texture around healed scars, but it does not lift a depressed scar. Rejuran S, the thicker preparation, is placed into and around scars. Tethered scars need subcision first, and depth decides between FSX Laser for superficial scars and the S3 Resurfacing Lift for deeper ones, so scars are mapped before any injection is planned.
After Rejuran Healer, avoid make-up, heat, alcohol and vigorous exercise for the first evening while the papules at the injection points begin to flatten, and use a cool compress for swelling. After that, a plain barrier-supporting routine and daily sunscreen are usually all that is asked. Pain that increases, spreading redness or warmth, or swelling that does not subside needs prompt review by the doctor who injected you.
Rejuran Healer is a polynucleotide skin booster that acts as a signal to the skin to repair, rather than a material that holds a shape. It is injected into the dermis as a field of micro-injections and is directed at uneven texture, fine lines, slackened elasticity and post-acne skin quality. It adds no volume, does not lift and does not remove pigment, so hollows, sagging and melasma are planned differently.
Rejuran is the brand; Rejuran Healer is the standard whole-face preparation within it, polynucleotide at about 20 mg/mL. When people say a Rejuran facial or Rejuran injections they usually mean Healer. Rejuran S is thicker for scarred skin, Rejuran I thinner for the under-eye, and Rejuran HB combines polynucleotide with hyaluronic acid.
No. Nothing in the syringe is engineered to occupy space or hold a contour. Polynucleotides act on the repair environment of the dermis, influencing fibroblast activity and signalling through adenosine receptor pathways. A hollow or a deficient contour is a structural problem that needs a different material, and a face that wants both is planned as two decisions.
Topical anaesthetic is applied first. The material is placed in a grid of closely spaced intradermal micro-injections by fine needle or an injector device, and each point raises a small papule that settles as the gel is taken up. Most people describe pinpricks and a mild sting rather than pain; bruising is possible and fades on its own.
Rejuran is registered with Singapore's Health Sciences Authority as an injectable medical device and is given by a doctor with sterile technique. The expected effects are local: papules, swelling, tenderness and bruising. Nodules and infection are uncommon; allergic reaction is rare, which is why fish allergy is checked first. It is not used in pregnancy, while breastfeeding or through active infection.
Yes, and Dr Sin Yong often pairs it with a resurfacing or RF microneedling session so that the repair signal is placed where the skin has been asked to heal. Whether to combine, and in what order, is decided at assessment and reviewed after the first visit rather than fixed in advance.
A first course is commonly three to four sessions about four weeks apart, because polynucleotide works through repair signalling that builds over weeks rather than on the day. After that, a single maintenance session every six to twelve months is typical, judged at review rather than sold in advance. Thin, sun-damaged or post-acne skin may need the longer course; well-kept skin may need less.
Singapore rules restrict how fees may be advertised, so no figure appears here. The quote depends on the number of syringes used per visit, the number of sessions in the course, whether the eye area or neck is added, and whether it is combined with laser or RF microneedling. Dr Sin Yong gives the fee in writing after the assessment, and the review visit is part of the plan.
References
Polynucleotides in aesthetic medicine: a review of current practices and perceived effectiveness. International Journal of Molecular Sciences (Lee KWA, Chan KWL, Lee A, et al.), 2024. source
A survey on the cosmetic use of injectable polynucleotide: the pattern of practice among Korean dermatologists. Journal of Cosmetic Dermatology (Rho NK, Han KH, Cho M, et al.), 2024. source
Lampridou S, et al. The Effectiveness of Polynucleotides in Esthetic Medicine: A Systematic Review. Journal of Cosmetic Dermatology, 2024. doi.org
About this page: written and medically reviewed by Dr Sin Yong, MBBS (NUS), MRCS (Edinburgh) · Last reviewed 6 November 2026 · Illustrative images only, not patients · Editorial policy
