Main guideRejuran aftercare — papules, cleansing, sunscreen and what to avoid, day by day.
Published 13 November 2026 · Reviewed by Dr Sin Yong
Rejuran leaves a pattern of small raised bumps, because the product is placed as many shallow deposits in the skin. They are expected and settle over the first few days. This page sets out what is normal, what is not, and what published studies say about side effects.
Short answerRejuran bumps are small raised points, called papules, at each injection site. They appear on the day, look dotted across the face, and flatten over the first one to three days as the skin takes up the polynucleotide; a little redness and tiny bruises are also expected. Increasing pain, spreading redness, or a bump that stays or grows is not expected. Dr Sin Yong performs Rejuran himself on Orchard Road, Singapore, and reviews anything that does not settle.
Rejuran is a polynucleotide, purified from salmon DNA, placed into the dermis as many small deposits, by hand or with an injector device. Each deposit sits as a raised point until the tissue takes the material up. Because the deposits are many and shallow, the face can look dotted for a short while.
Rejuran tends to settle a little more slowly than hyaluronic acid skin boosters. The thicker preparations are described on Rejuran Healer.
How long do Rejuran bumps last?
Swipe sideways to see the whole table.
When
What is expected
Same day
Small bumps at each injection point, redness, tiny bruises
Days 1 to 3
Bumps flatten; bruising may show
Weeks 1 to 4
Skin looks ordinary; texture changes gradually
These are typical ranges from Dr Sin Yong’s practice. Care during this time is on Rejuran aftercare.
What side effects do studies report?
A systematic review of polynucleotides in aesthetic medicine found nine studies with 219 treated patients, all of low or moderate quality, and reported that side effects were generally mild and short-lived (Lampridou 2025).
A second systematic review, of six studies with 350 participants treated around the eyes, also found a favourable safety record, and pointed out that no study followed patients for longer than six months (Ahuja 2026). The honest summary is that short-term safety looks good and long-term data are thin.
When is a bump not normal?
It is getting larger instead of flatter.
It is still there after the others have gone.
The skin around it is red, warm or tender, or the redness is spreading.
There is pus, or you feel unwell.
These need the doctor who treated you. A lump that persists after a skin booster is discussed on skin booster lumps.
Can Rejuran be dissolved?
No. Hyaluronidase breaks down hyaluronic acid and nothing else, and Rejuran is a polynucleotide. A bump that does not settle is therefore assessed, not dissolved. What hyaluronidase does and does not do is on hyaluronidase.
When is it urgent?
Urgent: a change in vision or eye pain after an injection means calling 995 now. Skin that turns white, pale, dusky or mottled, or pain that is getting worse, needs the doctor who injected you, or A&E, now.
Your next step
Not for emergencies. A change in vision or eye pain after an injection: call 995 now. Pale, dusky or mottled skin, or pain that is getting worse: go now to the doctor who injected you, or to A&E. Do not message or book for these signs.
1. MessageWhatsApp the clinic with what is bothering you, and the product and date if you know them. A reply comes from the clinic, not a bot.
2. AssessmentDr Sin Yong examines you himself on Orchard Road, with an ultrasound scan of the area.
3. A plan in writingWhat he would do, what he would not, the fee factors, and the option of no treatment.
Every treatment is performed by Dr Sin Yong personally. Singapore Medical Council registered · invited to share his clinical expertise internationally for CLASSYS, DEKA, Fotona, Hironic and Ilooda.
Anything that does not settle as expected is examined before any treatment. How consultations work.
Rejuran bumps usually flatten over the first one to three days. A bump that is still present after the others have gone, or that is growing, should be examined.
Yes. They are small deposits of the product in the skin at each injection point, and they settle as the tissue takes it up.
Expected effects are bumps, redness and small bruises. Published reviews describe side effects as generally mild and short-lived, with little follow-up beyond six months.
No. Hyaluronidase acts on hyaluronic acid only, and Rejuran is a polynucleotide. A persistent bump is assessed by a doctor.
No. Leave them alone, cleanse gently and avoid scrubs, acids and retinoids until the skin has settled.
If pain increases, redness spreads, a bump grows or persists, or there is pus. Skin colour change or any change in vision after an injection is an emergency.
References
Lampridou S, Bassett S, Cavallini M, Christopoulos G. The Effectiveness of Polynucleotides in Esthetic Medicine: A Systematic Review. Journal of Cosmetic Dermatology, 2025. source
Ahuja R, Khalil S, Galadari HI, Guida S. Efficacy of Polynucleotides in Periorbital Rejuvenation: A Systematic Review. Aesthetic Surgery Journal Open Forum, 2026. source
About this page: written and medically reviewed by Dr Sin Yong, MBBS (NUS), MRCS (Edinburgh) · Last reviewed 13 November 2026 · Illustrative images only, not patients · Editorial policy
Not for emergencies. A change in vision or eye pain after filler: call 995 now. Pale, dusky or mottled skin, or pain that is getting worse: go now to the doctor who injected you, or to A&E. Do not message or book for these signs.
