Medically reviewed by Dr Sin Yong · Last reviewed · 10 min read · Jump to questions
Published 25 October 2026 · Reviewed by Dr Sin Yong

Ellansé cannot be dissolved. It is made of polycaprolactone microspheres in a gel, and hyaluronidase, the enzyme that dissolves hyaluronic acid filler, has no effect on it. Nodules, excess volume or product that has spread are mapped with ultrasound first. Where it suits, Dr Sin Yong targets the excess with the Sculpting mode of Time Freeze Laser LCLR®.
Part of Filler Problems →
No. This is the single most important fact about correcting Ellansé, and the one most often misunderstood. Hyaluronidase, the enzyme used to dissolve filler, breaks down hyaluronic acid. Ellansé contains no hyaluronic acid. It is made of microspheres of polycaprolactone (PCL), a biodegradable polymer long used in medicine, suspended in a carboxymethylcellulose gel (Christen 2020; de Melo 2017). Neither part responds to the enzyme: in a review of 1,111 treatments, the authors note that polycaprolactone filler cannot be immediately removed by injecting an enzyme (Lin 2020).
Where Ellansé has been layered with hyaluronic acid filler or skin boosters in the same area, the hyaluronic acid can be dissolved selectively, which sometimes reduces the fullness around the Ellansé. The scan shows whether that applies. The enzyme will not change the polycaprolactone itself.
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Ellansé is a collagen stimulator. When it is injected, the gel gives volume straight away. The body then absorbs the gel, while the polycaprolactone microspheres stay in the tissue and prompt it to lay down collagen around them, which carries the longer-term volume. Different versions are made to last different lengths of time before the microspheres themselves are broken down (Christen 2020).
This is why Ellansé problems change over time. Early on, the gel and normal swelling can make an area look fuller than it will be. Later, a nodule may be a cluster of microspheres with collagen around it: firm, and not softened by massage. More on the product is on Ellansé in Singapore and in the glossary under polycaprolactone.
“What you see on the day after Ellansé is gel and swelling sitting over the product. I do not call it the result, and I do not add to it, until the gel has gone and the collagen has had its say.”
Dr Sin YongOn judging Ellansé
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| What you notice | What it often is | What is considered |
|---|---|---|
| A firm nodule you can feel or see | Microspheres clustered or placed too superficially, with collagen around them | Ultrasound; the Sculpting mode of Time Freeze Laser LCLR®, used for nodules large and small |
| Too much volume, or a heavy, puffy look | More product than the area needed, or collagen built up over repeated treatments | Mapping; the Sculpting mode of Time Freeze Laser LCLR® for the excess |
| Product that seems to have moved | Spread from where it was placed, or placement in a layer that allows movement | Mapping to see where it sits now |
| Bumps in the forehead or temples | Thin skin and fat over the area, where small amounts show easily | Ultrasound; the plan follows the depth |
| A red, tender or swollen lump, sometimes months later | Inflammation or infection; rarely a foreign-body granuloma | Medical treatment first |
| Fullness soon after treatment | The gel and normal swelling | Review rather than treatment, unless there are urgent signs |
In the review of 1,111 polycaprolactone treatments, the most common problems were swelling and bruising, and nodules and granulomas were described as rare (Lin 2020). Lumps from collagen-stimulating fillers can still be persistent: in a series of 55 such complications, nodules were the most common problem, and hyaluronidase helped only where hyaluronic acid had been mixed in (Ianhez 2024). A granuloma is managed with anti-inflammatory treatment, ideally guided by ultrasound (Cerón Bohórquez 2024), which is why a lump that is red, tender or growing is treated medically before anything else. The differences between collagen-stimulator nodules and migrated product are set out in collagen-stimulator nodules and migration.
Ultrasound is the first step for any Ellansé problem. Polycaprolactone has its own appearance on the scan, with bright specks and small comet-tail artefacts inside the deposit, which sets it apart from the dark, uniform pockets of hyaluronic acid (Wortsman 2017; Wortsman 2015).

The scan shows:
Some patients come only for mapping, to know what is there before deciding anything; that is a valid reason for an assessment. Dr Sin Yong performs the scan himself.
LCLR® stands for Laser Collagen Lipo Remodelling. It is a proprietary protocol developed by Dr Sin Yong on a long-pulsed 755 nm and 1064 nm laser platform, and he performs every treatment himself. Its Sculpting mode is built to target excess material. For Ellansé, it is the tool he uses on polycaprolactone nodules and excess, including where they sit with hyaluronic acid or skin boosters, and including under the eye after assessment and ultrasound.
How a hard lump forms after filler and skin boosters. Diagram, not to scale.
A cross-section of facial tissue builds up layer by layer: skin, fat, muscle and bone.
Different products, same area: hyaluronic acid filler, skin booster and collagen stimulator, placed at different times.
They merge into one firm lump with a thin capsule, pressing on surrounding tissue. Small red vessels can show above it.
An ultrasound probe glides across the skin, mapping the material and its depth; the lump outline is traced in gold.
Time Freeze Laser LCLR®, Sculpting mode: laser energy is directed at the mapped area, built to target the excess material.
Ultrasound first. No incision. Response varies from person to person. Dr Sin Yong, Orchard Road, Singapore.
Every face and every nodule is different, so the response varies from person to person. Like any medical treatment, laser has its own risks and limits, which are explained at the assessment alongside the alternatives. More on the protocol is on Time Freeze Laser LCLR®, and on the mode used for nodules in the Sculpting mode of Time Freeze Laser LCLR®.
Consensus recommendations on filler complications advise identifying the type of lump before choosing a treatment (Urdiales-Gálvez 2018), which is the reason the scan comes first.
You do not need to have been treated here. Patients travelling to Singapore can plan their visit through international patients, and doctors can refer through for GPs.
Many patients who come to see Dr Sin Yong about Ellansé problems tell him they have tried almost everything else and had given up hope. Having tried other treatments does not, on its own, rule out further options; what can be done depends on what the scan shows.
That history is useful. Knowing what was injected, when, and what has already been tried often explains why a problem has stayed: hyaluronidase acts only on hyaluronic acid and only where it reaches, some fillers are not hyaluronic acid at all, and swelling or fluid can look like filler. Ultrasound helps show which of these applies, and the plan starts from there. For material that cannot be dissolved, Dr Sin Yong uses the Sculpting mode of Time Freeze Laser LCLR® for nodules large and small, without an incision. How each person responds varies.
If you have been told nothing more can be done, it is still worth having the area scanned: ultrasound helps show what is there, and what, if anything, can be done is discussed from that. Bring any records of past treatments, product names and dates if you have them. More on this is in when filler dissolving has not worked.
The first job is to work out what the lump actually is. Dr Sin Yong maps before he treats, does not inject an enzyme that cannot work, dissolves any hyaluronic acid layered in the same area selectively, and uses the Sculpting mode of Time Freeze Laser LCLR® where excess collagen-stimulator material is the problem. The plan, including what he would not do, is set out in writing.
For lumps under the eye, see non-hyaluronic acid filler lumps under the eye; for hard lumps after mixed products, see filler complications; for fillers that can be dissolved, see filler dissolving in Singapore.
Every treatment is performed by Dr Sin Yong personally. Singapore Medical Council registered · invited to share his clinical expertise internationally for CLASSYS, DEKA, Fotona, Hironic and Ilooda.
Book an Ellansé assessment and ultrasound mapping with Dr Sin Yong on Orchard Road. How consultations work.
WhatsApp Dr Sin Yong →or use the enquiry formNo. Ellansé is polycaprolactone microspheres in a carboxymethylcellulose gel, and hyaluronidase, the enzyme that dissolves hyaluronic acid filler, does not act on either. Problems are managed instead: ultrasound maps the product, inflamed lumps are treated medically, and excess material can be targeted with the Sculpting mode of Time Freeze Laser LCLR® where it suits.
Many of the patients Dr Sin Yong sees have tried other treatments first. A treatment that did not help can still leave options open: hyaluronidase may not have reached the filler, the filler may not be hyaluronic acid, or what looks like filler may be swelling or fluid. Ultrasound helps show which applies, and the plan follows what it finds. What can be done varies from person to person.
Not by dissolving. Excess polycaprolactone can be targeted with the Sculpting mode of Time Freeze Laser LCLR®, which is built to target excess material with no incision; Dr Sin Yong uses it for nodules large and small. What suits depends on what the scan shows and where the product sits.
Early fullness and swelling after Ellansé often settle as the gel is absorbed. A firm nodule that persists is usually a cluster of microspheres with collagen around it, which does not settle in the way swelling does. A lump that is red, tender or growing needs prompt assessment rather than waiting.
It can help with the hyaluronic acid part. Where Ellansé has been layered with hyaluronic acid filler or skin boosters, ultrasound shows which is which, the hyaluronic acid can be dissolved selectively, and the Ellansé is reassessed afterwards. The enzyme will not change the polycaprolactone itself.
The skin and fat over the forehead and temples are thin, so small amounts of product, or product placed close to the surface, can show as bumps. Ultrasound shows the depth and size of each deposit, which decides what can be done; the Sculpting mode of Time Freeze Laser LCLR® is considered for excess material.
No. An established nodule is a cluster of microspheres with collagen around it, and massage does not break it up. Firm pressure can irritate an inflamed lump. Gentle massage is sometimes advised soon after treatment for unevenness of the gel, but only on the advice of the doctor who examined you.
Not every lump after Ellansé is Ellansé. It can be hyaluronic acid or a skin booster from another treatment, inflammation, or something unrelated such as a cyst or a lymph node. Ultrasound helps tell these apart, which is why it comes before any treatment.
Dr Sin Yong uses the Sculpting mode of Time Freeze Laser LCLR® under the eye, but only after assessment and ultrasound; whether it suits a particular under-eye depends on the depth and amount of product and the condition of the skin. Eye protection is used during any laser treatment near the eyes.
It helps to know, but the assessment goes ahead without it. Ultrasound shows where the product is and how much there is, which matters more for planning than the version. Bring any records, product cards or messages from the clinic if you have them.
Dr Sin Yong's approach to Ellansé does not involve surgery. Concerns are mapped first, then managed with medical treatment, the Sculpting mode of Time Freeze Laser LCLR®, which he uses for nodules large and small without an incision, or time, depending on what the scan shows. How each person responds varies.
Polycaprolactone: How a Well-Known and Futuristic Polymer Has Become an Innovative Collagen-Stimulator in Esthetics. Clinical, Cosmetic and Investigational Dermatology, 2020. source
Recommendations for volume augmentation and rejuvenation of the face and hands with the new generation polycaprolactone-based collagen stimulator (Ellansé®). Clinical, Cosmetic and Investigational Dermatology, 2017. source
Polycaprolactone-based dermal filler complications: A retrospective study of 1111 treatments. Journal of Cosmetic Dermatology, 2020. source
Complications of collagen biostimulators in Brazil: Description of products, treatments, and evolution of 55 cases. Journal of Cosmetic Dermatology, 2024. source
Ultrasound-guided Treatment of Polycaprolactone Granuloma. Plastic and Reconstructive Surgery Global Open, 2024. source
Ultrasound Morphology of Polycaprolactone Filler. Journal of Ultrasound in Medicine, 2017. source
Identification and Complications of Cosmetic Fillers: Sonography First. Journal of Ultrasound in Medicine, 2015. source
The Use of Hyaluronidase in Aesthetic Practice (v2.4). Journal of Clinical and Aesthetic Dermatology, 2018. source
Treatment of soft tissue filler complications: expert consensus recommendations. Aesthetic Plastic Surgery, 2018. source
About this page: written and medically reviewed by Dr Sin Yong, MBBS (NUS), MRCS (Edinburgh) · Last reviewed 26 October 2026 · Illustrative images only, not patients · Editorial policy
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