Dr Sin Yong · MBBS (NUS) · MRCS (Edin) · MSc Aesthetic Medicine (London) · MSc Practical Dermatology (Cardiff) · International KOL
Ellansé is polycaprolactone microspheres suspended in a gel carrier. The gel gives volume on the day; the collagen the skin builds around the microspheres is what remains — and none of it can be dissolved. Assessed and placed by Dr Sin Yong at Orchard Road, Singapore.
Ellansé is a suspension of polycaprolactone microspheres in a carboxymethylcellulose gel. Polycaprolactone is a synthetic polymer with a long history in resorbable sutures and implants; here it is formed into smooth spheres a few tens of microns across, which make up roughly 30% of the syringe. The remaining 70% is the gel that carries them.
The two components do different jobs on different timelines. The gel provides correction on the day, which is why Ellansé is sometimes described as a filler. Over the following weeks the gel is absorbed, and the microspheres that remain act as a scaffold: fibroblasts lay down new collagen around them, and that collagen is what provides the longer-term support. The microspheres themselves break down slowly to carbon dioxide and water.
It is therefore both a filler and a collagen stimulator, in sequence. That is useful, and it is also the source of most of the misunderstanding around it.

Because the gel gives an immediate correction, Ellansé is the one collagen stimulator that can be judged in the mirror on the day — and that judgement is usually wrong in both directions.
In the first weeks the gel carrier is absorbed and the volume it provided recedes, so a patient who was pleased on the day may believe the result has faded. Over the following months the collagen response builds around the microspheres, so volume returns in a more structural form. The final result is the collagen, not the gel, and it is not the same shape or quantity as what was visible on the day.
That sequence has a practical consequence: the product is dosed for the collagen it will produce, not for the gel it shows. Filling to a pleasing day-one result is how the lower face ends up heavier than intended months later, with no way to take it back.
Hyaluronidase reverses hyaluronic acid filler. It has no action on polycaprolactone or on the carboxymethylcellulose gel that carries it. Once placed, Ellansé is managed, not reversed.
Nodules are described with polycaprolactone as with every biostimulator. They are usually related to placement that is too superficial, to volume concentrated in one spot, or to mobile areas where the product is worked by muscle. Management depends on what the lump is, which is why ultrasound comes before any intervention; a lump that turns out to be previous hyaluronic acid filler is treated very differently from one that is polycaprolactone.
This is also why Dr Sin Yong will not place Ellansé over previous filler that has not been mapped. Correction of biostimulator problems from treatment elsewhere is assessed under filler correction.
“The gel you see on day one is not the result. The collagen that replaces it is — and by then it is too late to change your mind.”
Dr Sin YongOn why Ellansé is planned, not previewed
Ellansé rewards depth and punishes spread. Dr Sin Yong places it deep — on the periosteum or in the deep fat compartments where the anatomy allows — in small, deliberate deposits that give the collagen somewhere structural to form, rather than as a sheet in the superficial fat where a firm product shows through thin skin.
The face is treated as a structure, not a surface. The jawline is read as a line from chin to angle, and the temple and lateral cheek are assessed for how they support the lower face before anything is placed lower down. Where the goal is definition, he uses the firmer formulation sparingly and stages it; where the goal is diffuse support in thinner skin, the softer formulation or a different product altogether may be more defensible.
He under-treats at a first visit and reviews once the gel has gone and the collagen has begun to form, because that is the first point at which the real result can be judged.
It suits structural work in firm tissue: a chin that needs projection, a jawline that needs a cleaner line, temples and lateral cheeks that have hollowed, and the backs of the hands, where the tendons have become visible. It suits a patient who wants some change on the day but is choosing the product for the collagen that follows, and who understands it cannot be reversed.
It does not suit the lips, the tear troughs or the fine lines of thin, mobile skin. It does not lift a descended tissue plane; a jowl is a laxity problem for focused ultrasound or the VF Lift – Vertical Facelift, and adding volume below it makes the jowl heavier. And it is not the right first injectable in a face that has never been assessed; a reversible hyaluronic acid filler is the more forgiving place to start.
Against its neighbours: Sculptra gives almost no volume on the day and works more diffusely; Radiesse is calcium hydroxylapatite, also immediate plus stimulating, and is the one more often diluted for skin quality. Which fits is an anatomical decision.

A face that has been injected more than once often arrives with a complaint that sounds like it needs more product — a heaviness in the lower face, a fullness under the eyes, a lump that has appeared months after the last visit. In Dr Sin Yong's experience the opposite is more often true: the problem is what is already there, and the answer is subtraction, not addition.
So before any further Ellansé is placed, he scans. High-frequency ultrasound shows what material is sitting in the tissue, how deep it is, whether it has migrated, and whether a lump is polycaprolactone, old hyaluronic acid filler, a cyst, or scar. Each of those is managed differently, and two of them are made worse by injecting on top. A scan takes minutes and changes the plan more often than not.
If the scan shows that less is what you need, that is a different procedure with its own planning — see filler correction. If it shows a clean field, Ellansé can be placed with confidence rather than hope. Either way, nothing is added to a face that has not been looked beneath.
The common findings are swelling, bruising and tenderness at the injection sites, and a temporary firmness where the gel sits. Nodules and visible or palpable product are the specific risks of a firm, non-dissolvable material and are discussed above. The serious risks are vascular and attend any injectable placed near facial vessels, which is why depth, plane and anatomical knowledge matter more than the brand on the box.
Polycaprolactone is resorbed by the body over time and the collagen it produced ages with the rest of the face. The change is not lifelong, and no duration quoted to you is a prediction for your anatomy.
Christen MO, Vercesi F. Polycaprolactone: how a well-known and futuristic polymer has become an innovative collagen-stimulator in esthetics. Clinical, Cosmetic and Investigational Dermatology 2020;13:31–48. source
de Melo F, Nicolau P, Piovano L, et al. Recommendations for volume augmentation and rejuvenation of the face and hands with the new generation polycaprolactone-based collagen stimulator (Ellansé®). Clinical, Cosmetic and Investigational Dermatology 2017;10:431–440. source
Wortsman X. Identification and complications of cosmetic fillers: sonography first. Journal of Ultrasound in Medicine 2015;34(7):1163–1172. source
Health Sciences Authority. Infosearch — register of health products and medical devices approved for supply in Singapore. source
Singapore Medical Council. Guidelines on Aesthetic Practices for Doctors, 2016 Edition. source
Medically reviewed by Dr Sin Yong, MBBS (NUS), MRCS (Edinburgh) · Last updated 2 October 2026
Whether a firm, non-dissolvable biostimulator is the right answer depends on the structure of your face and on what has been injected before. Dr Sin Yong assesses that first.
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