{
  "what": "Profhilo is a stabilised hybrid cooperative complex of high- and low-molecular-weight hyaluronic acid, made by IBSA, injected at defined points to act on the skin itself. It is bio-remodelling, not a dermal filler, so it adds no volume or projection and is considered for skin quality concerns such as crepiness, dullness and fine surface lines, including the neck and hands. At Dr Sin Yong's practice on Orchard Road, Singapore, he assesses and places it himself using a modified BAP technique.",
  "key_facts": [
    "Composition: 32 mg high-molecular-weight and 32 mg low-molecular-weight hyaluronic acid in a 2 mL syringe (NAHYCO), stabilised thermally rather than with a chemical crosslinker such as BDDE",
    "Category: bio-remodelling, not volumising; it is not a dermal filler and not a mesotherapy cocktail",
    "BAP: Bio Aesthetic Points are a defined set of points per side, chosen for vascular safety and spread through the subcutaneous plane",
    "Modified BAP: Dr Sin Yong keeps the defined points as the safety framework, adds placement according to the individual face shape, and treats scarred skin alongside",
    "Does not: correct a hollow cheek, a flat bridge or a receded chin, which are volume questions for fillers or a collagen biostimulator",
    "Profhilo Structura: a separate IBSA product, placed by cannula into the superficial fat compartments of the lateral face for fat-compartment change rather than skin quality",
    "Expected effects: small raised deposits at the injection points that settle, bruising, tenderness and transient swelling; Profhilo lumps are hyaluronic acid and can be dissolved with hyaluronidase after a scan"
  ],
  "references": [
    "Stellavato A, Corsuto L, D'Agostino A, et al. Hyaluronan hybrid cooperative complexes as a novel frontier for cellular bioprocesses re-activation. PLoS ONE 2016. https://pmc.ncbi.nlm.nih.gov/articles/PMC5056743/",
    "Efficacy and tolerability of stable hybrid cooperative complexes of high- and low-molecular weight hyaluronic acid in Asian patients: an open-label study. https://pmc.ncbi.nlm.nih.gov/articles/PMC12916531/",
    "Tintor G, et al. Hybrid cooperative complexes of low- and high-molecular-weight hyaluronic acid in aesthetic medicine: a review including the Bio Aesthetic Points (BAP) technique. Pharmaceuticals 2026. https://www.mdpi.com/1424-8247/19/1/73"
  ],
  "owner_url": "https://drsinyong.com/profhilo-singapore/",
  "doctor": "Dr Sin Yong, aesthetic physician, Orchard Road, Singapore",
  "updated": "2026-10-30"
}