Main guideProfhilo aftercare — the bumps, make-up, exercise and sauna rules, day by day.
Published 13 November 2026 · Reviewed by Dr Sin Yong
Small raised bumps straight after Profhilo are part of the treatment, not a complication. The product is placed as a deposit at each injection point and spreads from there. A lump that grows, turns red and warm, or is still there after the others have gone is different, and should be examined.
Short answerProfhilo bumps are expected. The product is placed as a small deposit at each of five points on each side of the face, and each deposit shows as a raised bump until the hyaluronic acid spreads; they are left alone, not massaged. A bump that is getting larger, is red, warm or painful, or persists after the other points have settled is not expected and should be seen. Dr Sin Yong examines persistent lumps himself on Orchard Road, Singapore, with ultrasound where it helps.
Profhilo is not spread across the face in many tiny injections. It is placed as a deposit at each of five Bio Aesthetic Points on each side: the cheekbone, beside the nose, in front of the ear, the chin and the angle of the jaw. Each deposit sits under the skin as a raised bump until the hyaluronic acid, which is not cross-linked and flows easily, spreads through the tissue.
The bumps are therefore left alone. Massaging them is not part of the treatment. What to do day by day is on Profhilo aftercare.
Normal bump or a problem?
Swipe sideways to see the whole table.
Expected bump
Needs to be seen
When
Straight after treatment
Appears or grows later, or stays after the others have gone
Where
At the injection points
At one point, or away from the points
Look and feel
Soft, skin-coloured, flattening
Getting larger, firm, red, warm or tender
Skin over it
Normal, perhaps a small bruise
White, dusky, purple or net-like: this is urgent
What to do
Leave alone
Contact the doctor who treated you
Profhilo lumps not going down
A lump that is still there once the other points have settled has a short list of possible causes: product that has not spread from one point, a bruise or collection of blood, a reaction to the product, or infection. They are told apart by examination, and by ultrasound where the answer is not obvious.
Profhilo is hyaluronic acid, so it can be broken down by hyaluronidase where that is the right step. That decision follows the examination. How dissolving is done here is on filler dissolving in Singapore.
How often do problems happen?
A safety review by the manufacturer covered spontaneous reports from the first three years on the market, during which more than 40,000 patients were treated. Twelve adverse event reports were logged and none was classed as serious. Swelling, redness and bruising soon after injection were the most frequent; swelling and nodules appearing later came next, with two late-onset reactions. The reports were attributed to local hypersensitivity or injection technique, and all resolved (Cassuto 2020).
Two cautions apply. The review was written by authors linked to the manufacturer, and it relied on voluntary reports, so minor events are likely to be under-counted, as the authors themselves note.
When is a lump after Profhilo urgent?
Urgent: a change in vision or eye pain after an injection means calling 995 now. Skin that turns white, pale, dusky or mottled, or pain that is getting worse, needs the doctor who injected you, or A&E, now.
Redness that is spreading, warmth, pus at a point, or a bump that keeps getting larger needs a doctor the same day.
How Dr Sin Yong assesses a Profhilo lump
History. When the treatment was done, which points, and how the lump has changed.
Examination. Size, firmness, warmth and the skin over it.
Ultrasound where useful. To see whether the lump is product, fluid or something else, and how deep it sits.
Plan. Observation, medical treatment for inflammation or infection, or dissolving under ultrasound guidance after a skin test, according to what is found.
Your next step
Not for emergencies. A change in vision or eye pain after an injection: call 995 now. Pale, dusky or mottled skin, or pain that is getting worse: go now to the doctor who injected you, or to A&E. Do not message or book for these signs.
1. MessageWhatsApp the clinic with what is bothering you, and the product and date if you know them. A reply comes from the clinic, not a bot.
2. AssessmentDr Sin Yong examines you himself on Orchard Road, with an ultrasound scan of the area.
3. A plan in writingWhat he would do, what he would not, the fee factors, and the option of no treatment.
Every treatment is performed by Dr Sin Yong personally. Singapore Medical Council registered · invited to share his clinical expertise internationally for CLASSYS, DEKA, Fotona, Hironic and Ilooda.
A lump that persists is examined, and scanned where useful, before anything is done. How consultations work.
Raised bumps at the injection points straight after Profhilo are expected. They are deposits of the product and flatten as it spreads. A lump that grows, turns red or warm, or persists after the others have settled is not expected.
They flatten on their own as the hyaluronic acid spreads through the tissue. A bump that is getting larger instead of smaller, or is still present once the other points have settled, should be examined.
No. The product is designed to spread on its own from each point, so the bumps are left alone.
Contact the doctor who treated you. Possible causes include product that has not spread, a bruise, a reaction or infection, and they are told apart by examination and ultrasound.
Profhilo is hyaluronic acid, which hyaluronidase breaks down. Whether dissolving is the right step is decided after the lump has been examined.
Skin that turns white, dusky or net-like, severe or increasing pain, or any change in vision after an injection needs urgent medical attention.
References
Cassuto D, Delledonne M, Zaccaria G, Illiano I, Giori AM, Bellia G. Safety Assessment of High- and Low-Molecular-Weight Hyaluronans (Profhilo) as Derived from Worldwide Postmarketing Data. BioMed Research International, 2020. source
About this page: written and medically reviewed by Dr Sin Yong, MBBS (NUS), MRCS (Edinburgh) · Last reviewed 13 November 2026 · Illustrative images only, not patients · Editorial policy
Not for emergencies. A change in vision or eye pain after filler: call 995 now. Pale, dusky or mottled skin, or pain that is getting worse: go now to the doctor who injected you, or to A&E. Do not message or book for these signs.
