Medically reviewed by Dr Sin Yong · Last reviewed · 8 min read
Where pigment keeps returning on a reactive, reddish background, R2T2 adds R2 Glow to the pigment pass.
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To lower the risk of new marks after treatment, follow pico laser aftercare.
In Vietnamese: laser pico cho thâm sau mụn (tiếng Việt).
See also: pico laser for dark skin.
Laser is the last of four stages; the full sequence is on PIH treatment Singapore.
Published 7 October 2026 · Reviewed by Dr Sin Yong

Pico laser for post-inflammatory hyperpigmentation (PIH) is considered only once the inflammation that caused the mark has been controlled, because a laser is itself a controlled injury and can deepen the mark it is meant to clear. Low-energy picosecond toning fragments the leftover pigment; the cause, sun protection and patience do most of the work.

Post-inflammatory hyperpigmentation is confirmed by its history: a mark in the shape of something that happened there before. Before pico laser is discussed, Dr Sin Yong asks what preceded the mark, whether acne, eczema, an insect bite, a burn, friction, a chemical peel or a previous laser, and whether that cause is still active. The post-inflammatory hyperpigmentation page describes the condition; this page covers only the picosecond laser's place in managing it.
Depth decides how the mark behaves. Pigment that sits in the epidermis looks brown, has a defined edge and tends to clear faster; pigment that has dropped into the dermis looks grey or slate-blue, has a softer edge and clears slowly or incompletely. Examination under appropriate light helps judge which applies, and a pink or red mark is separated out as post-inflammatory erythema, which is vessels rather than pigment and is not a picosecond target. Melasma, which can be mistaken for PIH on the cheeks, is also ruled out, because it is managed differently.

Pico laser fragments the melanin that inflammation has left behind so that the skin clears it faster than it otherwise would. The picosecond pulse does this mainly by a pressure effect, with less heat spreading into the surrounding skin than a longer pulse produces, which matters in a mark that exists because the skin over-responds to injury. It is delivered as low-energy toning across the mark rather than as the higher-energy spot treatment used for a sun spot.
It is not the first step because PIH fades on its own once its cause has stopped, and because every laser pass is itself an injury. Controlling the acne or eczema, stopping the friction, protecting the skin from the sun and allowing time clears many marks without any device. Toning is considered for marks that are persisting after the cause is controlled, that trouble the person and whose depth suggests they will respond. The acne treatment page covers how the commonest cause is brought under control.
How pico compares with other lasers for each type of pigment is set out on laser pigmentation removal in Singapore.
“Pigment already deposited is a deposit. Inflammation is what keeps producing it.”
Dr Sin YongOn treating upstream or downstream
Settings for PIH are chosen on the assumption that the skin will over-react, because it already has once. A longer wavelength that epidermal melanin absorbs less strongly, a low fluence, a larger spot and long intervals between treatments all reduce the heat and inflammation delivered to the surrounding skin. In Fitzpatrick IV and V skin a small test area is often treated first, and the response at review decides whether the plan continues or stops.
A stop rule is part of the plan. A mark that darkens after a treatment is reviewed and rested rather than treated again, and toning is not repeated on a standing schedule, because frequent repeated toning of the same area has been linked to pale mottled spots. A recent tan, active inflammation in the area, photosensitising medication and recent isotretinoin are each reasons to defer. The article on pico laser on Asian skin explains why these variables matter more than the device name.
The table sets out the post-inflammatory marks seen at consultation and whether low-energy picosecond toning is considered for each, the caution attached and what comes first or instead. Every row starts from the same rule: a mark that keeps being made cannot be cleared, so the cause is controlled before any laser. The PIH page describes the condition in full.
| Presentation | Candidate for toning? | Caution | Alternative or first step |
|---|---|---|---|
| Epidermal brown mark persisting after the cause has stopped | Considered | Low fluence, larger spot, longer wavelength, long intervals and a stop rule for any mark that darkens | Time, sun protection and topical therapy; many marks clear without a device |
| Marks with the cause still active, such as acne, eczema or friction | Not yet | New marks form behind the old ones while inflammation continues | The acne or eczema is controlled first and the friction stopped |
| Grey or slate-blue mark with a soft edge | Cautiously, if at all | Pigment has dropped into the dermis and clears slowly or incompletely | Expectations set at consultation; a different wavelength logic may apply |
| Pink or red mark | No | This is post-inflammatory erythema, vessels rather than pigment, and not a picosecond target | A laser absorbed by blood, or the R2 Glow protocol, is the category considered |
| Fitzpatrick IV to V skin with a history of darkening | Considered after a test area | The skin has already shown that it over-reacts to injury | Prescription topicals that slow pigment production, chosen by a doctor after assessment |
| Recent tan, photosensitising medication or recent isotretinoin | Deferred | Each raises the chance that the laser writes a new mark | Waiting, with sun protection, then reassessment |

Yes. The same laser that clears a post-inflammatory mark can create one, because the mark is the skin's response to injury and a laser is an injury. Energy too high for the skin, passes stacked over the same area, treatment repeated before the skin has settled, sun on freshly treated skin and treating over active inflammation are the usual causes. The darkening that follows tends to fade with time and protection, but it can take a long time, which is why prevention carries more weight than correction.
The other risks are those of any toning plan: pale or mottled spots from frequent repetition, transient redness and warmth, and uncommonly blistering or pinpoint bleeding at higher energies. Picking at any fine crust, scrubbing the area or restarting exfoliating acids too soon each add inflammation. New darkening weeks after treatment should be reviewed rather than treated over, and the complication care page lists the signs that need same-day attention.
Treating the cause is combined with every PIH plan, because a mark that keeps being made cannot be cleared. Acne is brought under control, eczema is settled, friction from masks, straps or rubbing is identified and stopped, and squeezing is discouraged, because each new episode of inflammation places another deposit. Daily broad-spectrum sun protection follows, since ultraviolet exposure deepens a fresh mark and slows its clearance.
Topical therapy is the next layer, and it is a doctor's decision rather than a shelf purchase. Prescription agents that slow pigment production or speed cell turnover, such as hydroquinone, tretinoin or azelaic acid, each have side effects and are chosen after assessing the skin and the cause. The fee for a plan that includes toning depends on the area, the depth and extent of the marks, whether a test area is treated first and how the plan is staged; Singapore's rules prevent prices from being advertised, and a written quote follows assessment, as the how fees are quoted page explains.
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WhatsApp Dr Sin Yong →or use the enquiry formNot until the inflammation has settled and the cause is controlled; no interval is fixed in advance. A fresh mark is still being made, and lasering through active inflammation adds injury. Many fresh marks fade with protection alone, so the laser is considered for marks that persist.
Less predictably. Pigment that has dropped into the dermis clears slowly, and the longer 1064 nm or 785 nm wavelengths are chosen because they reach further and are absorbed less by the epidermis. Response varies between individuals, and a test area is often treated first.
Often the two are planned together, with the cream slowing pigment production while the laser is directed at the deposit, but the timing around each treatment depends on the agent and how reactive the skin is. Tell Dr Sin Yong everything you apply, including products bought online.
Usually because the energy, interval or sun exposure was wrong for skin that is already prone to darkening. The mark that follows is new PIH on old PIH. It tends to fade with time and strict protection, and it should be reviewed rather than treated over again.
The logic is the same, but body skin heals more slowly and darkens more readily, so settings are more conservative and intervals longer. Friction from clothing and sun exposure on the site are addressed first. The underarm treatment page covers one common body site.
Postinflammatory hyperpigmentation. DermNet, 2023. source
How to fade dark spots in darker skin tones. American Academy of Dermatology, 2024. source
A Systematic Review of Picosecond Laser in Dermatology: Evidence and Recommendations. Lasers in Surgery and Medicine, 2021. source
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