Medically reviewed by Dr Sin Yong · Last reviewed · 10 min read · Jump to questions
Published 20 October 2026 · Reviewed by Dr Sin Yong

Acne in pregnancy is common, often appears or worsens in the first trimester, and is treated differently because several standard acne medicines are avoided. Isotretinoin, oral tetracyclines, topical retinoids, hydroquinone and high-strength peels are set aside; a small number of topical agents are generally used after discussion with the obstetrician. Dr Sin Yong plans around the pregnancy and defers elective procedures.
Part of Skin types and life stages →
Acne in pregnancy is managed with the obstetrician deciding first. Azelaic acid, topical clindamycin, limited-area benzoyl peroxide and low-strength glycolic acid are among the options generally used after that discussion; isotretinoin, tetracyclines, topical retinoids and spironolactone are avoided. Lasers, energy devices, injectables and medium-depth peels wait until after delivery and breastfeeding.
Pregnancy raises androgens and progesterone, both of which increase sebaceous gland activity, and in the first trimester that shift is steep. The result for many women is acne that starts, returns after years of clear skin, or worsens, often on the lower face and jaw and sometimes on the chest and back. For some it settles in the second or third trimester as hormone levels plateau; for others it persists until after delivery, and a few see it only after birth. A history of acne before pregnancy, or acne that flares before periods, makes a pregnancy flare more likely.

The acne itself is ordinary acne: the same four drivers of sebum, follicle blockage, Cutibacterium acnes and inflammation set out on acne treatment Singapore. What changes is the treatment, because the standard ladder contains medicines that are avoided when a baby is developing or feeding, and because elective procedures are deferred. Pregnancy also changes the skin around the acne: melasma often appears or darkens, the skin may be more sensitive, and marks left by inflammation can pigment more readily, which is one reason gentle control is still worthwhile rather than simply waiting.
The treatments below are avoided or restricted in pregnancy on the basis of known harm, biological plausibility or absence of safety data. The default where evidence is absent is to wait, because acne is not an emergency and nothing elective justifies an unknown risk to a pregnancy. The table reflects the American Academy of Dermatology's acne guideline and public guidance, the American College of Obstetricians and Gynecologists' guidance on skin conditions in pregnancy, and the published reviews of acne treatment in pregnancy and lactation; the obstetrician's advice for any individual pregnancy takes precedence over all of it.
| Treatment | Pregnancy | Breastfeeding | Why |
|---|---|---|---|
| Oral isotretinoin | Avoided; stopped immediately if pregnancy is found | Avoided | A known cause of serious birth defects (retinoic acid embryopathy); strict contraception is required for anyone who could become pregnant while taking it |
| Oral tetracyclines: doxycycline, minocycline, tetracycline | Avoided; the AAD advises stopping by the 15th week at the latest, and the obstetrician decides any earlier use | Generally avoided for prolonged courses | Deposit in developing teeth and bone |
| Topical retinoids: tretinoin, adapalene, tazarotene, cosmetic retinol | Avoided | On a doctor's advice; usually deferred | Same drug family as isotretinoin; absorption is low but the precaution is standard |
| Spironolactone and other hormonal acne treatments | Avoided | Doctor's decision | Anti-androgen effect on a developing fetus |
| Hydroquinone for the marks acne leaves | Not used without supervision; usually avoided | Deferred | Notable systemic absorption and no safety data |
| High-strength or medium-depth salicylic acid peels | Avoided | Deferred | Salicylates absorbed over a large area; low-strength spot use is a separate question for the doctor |
| Energy devices: lasers, IPL, radiofrequency, focused ultrasound | Elective use deferred | Many deferred; decided by device | Not studied in pregnancy; no evidence of safety for elective use, and the skin is changing anyway |
| Dapsone, some oral antibiotics such as trimethoprim | Avoided or used with great caution | Doctor's decision | Specific concerns in particular trimesters |
Two notes on the retinoid row. A cosmetic retinol bought over the counter is a retinoid and is stopped in pregnancy and when trying to conceive, not only prescription tretinoin. And exposure to a topical retinoid before a pregnancy was known is a reason to tell the obstetrician, not a reason for alarm, because absorption through the skin is low; the precaution exists so that the question never has to be asked.
“In pregnancy I treat the acne I can treat safely and I plan the rest. The obstetrician decides what goes on the skin; I decide what order the work happens in afterwards.”
Dr Sin YongOn acne in pregnancy
A small number of treatments are generally regarded as reasonable in pregnancy, and they are enough for most pregnancy acne, which is usually mild to moderate. Each is used after the obstetrician has been asked, on the smallest area and at the lowest strength that works, and the routine around them is kept simple.

| Treatment | What it does | Usual position |
|---|---|---|
| Azelaic acid | Acts on follicle blockage, bacteria and inflammation, and on the brown marks acne leaves | Thought to be safe in pregnancy; often the first topical chosen, and useful for post-acne marks where hydroquinone is avoided |
| Topical clindamycin or erythromycin | Reduce bacteria and inflammation | Generally regarded as acceptable; used in combination rather than alone, for a limited period |
| Benzoyl peroxide | Reduces bacteria without resistance | Low absorption; used on limited areas after the doctor has been asked |
| Low-strength glycolic acid | Loosens plugs at the surface | Minimal absorption; acceptable in low-strength products on small areas |
| Oral antibiotics from the penicillin or cephalosporin group, or erythromycin | Reduce inflammation in moderate to severe acne | Chosen by the doctor where topicals are not enough; the agent and timing are an individual decision with the obstetrician |
| Gentle routine and sun protection | Removes irritants; limits the pigmentation of marks and of melasma | Always; a mild cleanser twice daily, a plain moisturiser and a broad-spectrum sunscreen |
Light-based treatment occupies a middle ground. Public guidance from the American Academy of Dermatology describes lasers as relatively safe in pregnancy with a dermatologist's assessment, while the broader position on elective aesthetic lasers is to wait. At this practice elective laser work for acne is deferred during pregnancy, since medical control is usually sufficient and the reasoning for deferring elective treatment applies. Where acne is severe and distressing, the decision is made with the obstetrician and, where needed, a dermatologist.
Picking and squeezing are discouraged as firmly as in any other acne, because the marks that follow pigment more readily in pregnancy and the pigment-lightening agents that would usually treat them are among the things avoided.
Elective aesthetic procedures are deferred in pregnancy because their safety in pregnant women has not been studied, nothing about them is urgent, and the skin and face are changing anyway. The acne-related procedures that wait are set out below, with what is done meanwhile.
| Procedure | Usual position | What happens meanwhile |
|---|---|---|
| Lasers directed at inflammation (R2 Glow, 少女光), laser toning for marks | Deferred | Medical control, azelaic acid for marks, strict sun protection |
| Acne scar work: fractional CO2, FSX, RF microneedling, subcision, TCA CROSS | Deferred; and in any case not started while acne is active | Scars are classified and the sequence planned for after delivery; see acne scar treatment |
| Chemical peels beyond low-strength glycolic | Deferred | Low-strength topical use on small areas after advice |
| Cortisone injection into a single painful cyst | A doctor's decision; small dose, local, weighed against distress | Warm compresses, topical treatment, no squeezing |
| Hydrafacial and medical facials | Assessed individually; the acid step and boosters are adjusted or omitted | Gentle cleansing at home |
| Injectables, radiofrequency, HIFU and other elective treatments | Deferred in pregnancy and usually in breastfeeding | Planning consultation, skincare and sun protection |
Deferral is not neglect. The plan is made during pregnancy, which is a good time for it: the acne is graded, look-alikes are excluded, the routine is simplified, any marks or early scars are mapped, and the order of work after delivery is agreed, so that nothing is lost to waiting. The acne-to-scar pathway describes that order, and it does not change because the first stage happened during a pregnancy.
Breastfeeding is a different question from pregnancy, and usually a less restrictive one, but the default remains to ask before using anything. The question for each medicine is whether a meaningful amount reaches the milk and whether it matters to the infant. The published reviews of acne treatment in lactation and the current acne guideline draw broadly the same lines.
Elective procedures remain deferred for many women while breastfeeding, particularly injectables and heating devices, while some are assessed individually. Dr Sin Yong's general position on treatments in breastfeeding is set out on the pregnancy and breastfeeding page. Two practical points: anything applied to the chest is kept well away from the nipple and areola, and the postpartum months bring their own skin changes, including shedding hair and persisting melasma, which are assessed in the same visit rather than treated piecemeal. The post-pregnancy stretch marks page and the melasma page cover the two most common companions of postpartum acne.
Every decision about a medicine in pregnancy is made with the doctor who is responsible for the pregnancy. Dr Sin Yong does not prescribe for a pregnant patient over the obstetrician's advice, and where the two have not spoken, the first step is a note or a call. That is not caution for its own sake; the obstetrician knows the history of the pregnancy, any complications, and the other medicines in use, and an acne plan has to fit around all of it. Where acne is severe enough to need oral treatment, a dermatologist may be involved as well.
Aftercare in broad terms is the same simple routine kept up, sun protection every day, no picking, and a review after delivery. Consultations are described under how consultations work; a planning consultation during pregnancy is welcome, and no procedure is booked from it.
Every treatment is performed by Dr Sin Yong personally. Singapore Medical Council registered · invited to share his clinical expertise internationally for CLASSYS, DEKA, Fotona, Hironic and Ilooda.
Bring your obstetrician's details and a list of everything you apply or take, so the plan can be agreed with them. How consultations work.
WhatsApp Dr Sin Yong →or use the enquiry formGenerally, azelaic acid, topical clindamycin, benzoyl peroxide on limited areas and low-strength glycolic acid are regarded as reasonable, after your obstetrician has been asked, on a simple routine with sunscreen. Where acne is severe, a doctor may choose an oral antibiotic from a group considered compatible with pregnancy. Retinoids, tetracyclines, isotretinoin, spironolactone and hydroquinone are avoided. The obstetrician's advice comes first.
Stop it and tell your obstetrician at the next contact. Topical retinoids are avoided in pregnancy as a standard precaution because they belong to the same family as isotretinoin, but absorption through the skin is low, so an exposure before the pregnancy was known is a reason to inform, not to panic. Oral isotretinoin is different and needs an immediate conversation with the prescribing doctor and the obstetrician.
Elective lasers, radiofrequency, peels beyond low-strength glycolic and injectables are deferred during pregnancy at this practice, because their safety has not been established and acne can usually be controlled medically meanwhile. A medical facial may be assessed individually with the acid step adjusted or left out. The plan for lasers and scar work is made during pregnancy and starts after delivery or breastfeeding.
Usually more freely than in pregnancy, but still after asking. Azelaic acid, benzoyl peroxide and topical clindamycin on limited areas, kept away from the breast, are generally regarded as compatible, and short courses of certain oral antibiotics are a doctor's decision. Isotretinoin, prolonged tetracyclines, hydroquinone and strong peels are avoided, and retinoids are usually deferred until feeding ends.
It can, in the same way any inflamed acne can, which is why gentle control is still worthwhile rather than waiting it out. The marks it leaves pigment more readily in pregnancy and are treated with fewer tools, so sun protection and not picking matter more than usual. Marks and any scars are mapped during pregnancy and treated in sequence after delivery, once the acne is quiet.
Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology 90(5) (Reynolds RV et al.; PubMed 38300170), 2024. source
Is any acne treatment safe to use during pregnancy?. American Academy of Dermatology Association, public information, 2024. source
Skin Conditions During Pregnancy. American College of Obstetricians and Gynecologists, patient FAQ, 2024. source
Treatment of acne vulgaris during pregnancy and lactation. Drugs 73(8) (Kong YL, Tey HL; PubMed 23657872), 2013. source
Treatment of Acne in Pregnancy. Journal of the American Board of Family Medicine 29(2) (Chien AL et al.; PubMed 26957383), 2016. source
About this page: written and medically reviewed by Dr Sin Yong, MBBS (NUS), MRCS (Edinburgh) · Last reviewed 20 October 2026 · Illustrative images only, not patients · Editorial policy
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