Medically reviewed by Dr Sin Yong · Last reviewed · 9 min read · Jump to questions
Published 28 October 2026 · Reviewed by Dr Sin Yong

Nasolabial fold filler softens a smile line by placing product in or beneath the crease. It helps most when the fold is etched at rest and the cheek above it already has support. When the fold comes from a cheek that has descended or deflated, filling the line alone adds weight beside the mouth. That is why the cheek is assessed first and the line treated last.
Part of Nasolabial folds →
Nasolabial fold filler helps when the crease itself is part of the problem. The fold runs from the side of the nose to the corner of the mouth, and every face has it when smiling. With age it can become etched into the skin, so it stays visible at rest. That etched part is what filler in the line is for.
It tends to help in these situations:
The evidence supports filler for this area. A systematic review and meta-analysis of randomised trials found that tissue fillers improve the nasolabial fold area, and modern technique reads that evidence anatomically: placement and amount decide whether the result looks natural (Aesthetic Plastic Surgery 2021).
What filler cannot do is just as important. It does not lift a cheek that has slid, it does not tighten lax skin, and it should not try to erase the fold. A visible line is part of every adult face; aiming for a creaseless lower face takes so much product that the face looks heavy.
Filling the nasolabial fold makes it worse when the fold is a symptom of what is happening above it. Facial fat sits in separate compartments, and with age the compartments of the cheek deflate and slide downward (Rohrich 2007). Descending tissue piles against the fold. Filler placed in the crease lifts the floor of the line towards tissue that keeps arriving, and the shadow returns.
Chasing that shadow with more product causes the problems people fear:
If filler is already in the fold and it looks heavier than before, adding more is not the answer. Ultrasound shows what is there and where it sits, and hyaluronic acid can be dissolved with hyaluronidase. Problems after filler in the folds are covered on smile line filler gone wrong.
“Filler in the fold is the finishing step, never the opening one. If the cheek above is still coming down, the line will come back however much is put in it.”
Dr Sin YongOn nasolabial fold filler
Dermal fillers for smile lines are planned with the cheek above treated first. The fold is where the cheek meets the firmer upper lip, so what happens to the cheek decides how deep the fold looks. Restoring support at the cheek reduces how much tissue gathers against the fold, and the line often softens before any product goes near it.
The cheek is assessed for three things, each with its own answer:
| What the cheek shows | What it needs | Where the fold fits |
|---|---|---|
| Deflation: a flat cheek above a deepening fold | Support placed on the bone of the cheek | Fold treated afterwards, if a line remains |
| Descent: cheek tissue sitting lower | Lifting, such as VF Lift – Vertical Facelift for the mid-face, HIFU or a thread lift | Filler in the fold avoided until descent is addressed |
| Fullness: the inner cheek is heavy | Reduction, or dissolving if old filler is the cause | More product in the fold avoided |
For a fold fed by a descended cheek, Dr Sin Yong's threadless protocol, RVR ProLift, places biodegradable product along mapped vertical vectors to re-support the deeper structure. Why cheeks drop is explained on sagging cheeks.
The principle is the same whichever tools are used: the crease receives the least filler of anywhere in the plan, and it comes last.
The filler for nasolabial lines depends on where it is going: into the fold itself, or into the support above and beneath it. The materials behave differently, and hyaluronic acid is the one that can be dissolved.

| Material | What it does | Can it be dissolved? | Where it tends to be used |
|---|---|---|---|
| Hyaluronic acid (HA) | A gel that occupies space; softness chosen for the layer | Yes, with hyaluronidase | The fold itself, where reversibility matters |
| Calcium hydroxylapatite (CaHA) | Firm microspheres that support and prompt the body's own collagen | No | Support on the bone, away from the surface of the fold |
| Polycaprolactone (PCL) | Microspheres in a gel that act as a scaffold for collagen | No | Support on the bone |
| PLLA biostimulator | Prompts collagen gradually across an area | No | Broader volume support, planned cautiously |
In bone-support areas Dr Sin Yong usually uses CaHA or PCL. In the fold itself, a soft hyaluronic acid filler is usually preferred, because it can be dissolved if it moves, forms a lump or simply is not wanted. Collagen-stimulating products do not dissolve in the same way, which makes conservative planning more important wherever they are considered. How each filler type is used across the face is set out in the guide to dermal fillers in Singapore.
No brand is named here. What matters is the material, the layer it is placed in, and the amount, which are decided at assessment.
Nasolabial fold filler is a common treatment, but the area carries real risks, and knowing them helps you choose where and by whom it is done.
The facial artery and its branches run close to the fold, so a blocked blood vessel is a recognised risk here. Skin that turns pale, dusky or mottled beside the nose or on the upper lip, or pain that is getting worse, needs urgent assessment. Any change in vision or eye pain after filler means calling 995 or going to the nearest emergency department straight away. The signs are listed on warning signs after filler.
These risks are reduced by anatomy-led placement, conservative amounts, using hyaluronic acid where reversibility matters, and keeping hyaluronidase on hand. They are reduced, not removed.
Dr Sin Yong assesses and injects himself on Orchard Road. The fold is examined at rest and in a smile, from the front and in profile, together with the cheek above it, the jawline below and the quality of the skin. Earlier filler or threads are recorded, and ultrasound is used where product is already present, because a heavy fold is sometimes old filler rather than ageing.
He treats the cause first and the crease last, and conservatively. Many consultations about the fold end with a plan that starts in the cheek, and some end with no filler in the fold at all.
Expect some swelling and tenderness. Avoid pressing or massaging the area unless you are told to, and avoid strenuous exercise, saunas and facial treatments until you are told it is fine. Call the clinic for skin colour change, increasing pain or swelling, or a lump that becomes red or tender. The fold is reviewed once swelling has settled, and any further step is decided then. Fees follow the plan and are set out after examination; see how fees are quoted.
Every treatment is performed by Dr Sin Yong personally. Singapore Medical Council registered · invited to share his clinical expertise internationally for CLASSYS, DEKA, Fotona, Hironic and Ilooda.
Book an assessment with Dr Sin Yong on Orchard Road. Bring the names and dates of any earlier filler in the cheeks or folds. How consultations work.
WhatsApp Dr Sin Yong →or use the enquiry formNo, and it should not try. Every adult face has a nasolabial line when smiling, and erasing it takes so much filler that the lower face looks heavy. The realistic aim is a softer shadow at rest. That usually comes from supporting or lifting the cheek above first, with a small amount of filler in the fold for any crease that remains.
It depends on the cheek. If the cheek has deflated, support there often softens the fold more naturally than product in the line. If it has descended, lifting is considered before either. Filling the fold alone suits a crease etched at rest in a face whose cheek is still well supported. Most plans start above the fold and treat the line last.
No duration is promised. How long filler stays depends on the product, the layer it is placed in, how much movement the area has, and your own metabolism, and the face continues to age around it. Hyaluronic acid can also persist longer than people expect, which is one reason top-ups are planned at review rather than on a schedule.
Most people feel pressure and a brief sting at the injection points. A numbing cream is commonly used, and many fillers contain a local anaesthetic, which eases discomfort as the product goes in. The area can feel tender and swollen afterwards. Tell the doctor straight away about pain that is severe or getting worse, because that is not expected.
Often, but earlier product is assessed first. Filler can stay longer than expected and can move, so ultrasound is used to see what is already in the fold and the cheek. If the area is heavy with old product, dissolving it comes before anything new. Bring the names and dates of earlier treatments if you have them.
Avoid pressing or massaging the area unless told to, and hold off strenuous exercise, saunas, facials and dental work until you are told it is fine. Keep the area clean and avoid make-up over the injection points at first. Call the clinic for pale or dusky skin, increasing pain, or a lump that becomes red or tender.
Tissue Fillers for the Nasolabial Fold Area: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Aesthetic Plastic Surgery, 2021. source
The fat compartments of the face: anatomy and clinical implications for cosmetic surgery. Plastic and Reconstructive Surgery, 2007. source
About this page: written and medically reviewed by Dr Sin Yong, MBBS (NUS), MRCS (Edinburgh) · Last reviewed 28 October 2026 · Illustrative images only, not patients · Editorial policy
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