Medically reviewed by Dr Sin Yong · Last reviewed · 3 min read
Published 13 October 2026 · Reviewed by Dr Sin Yong

Calcium hydroxylapatite (CaHA) is a biocompatible mineral, chemically similar to the mineral in bone and teeth, used in aesthetic medicine as microspheres of 25 to 45 µm suspended in a gel carrier. CaHA is the material in Radiesse. Undiluted, it gives volume on the day and stimulates collagen afterwards; diluted, it becomes a skin-quality treatment for the face, neck and body. Hyaluronidase does not dissolve either form.

CaHA appears wherever this site discusses support on bone rather than volume in soft tissue. Because the microspheres are firm and cannot be dissolved, every page that uses it pairs it with ultrasound mapping and a conservative first placement.
CaHA is chosen for support on bone; if a plan needs something that can be taken back, it is the wrong material.— Dr Sin Yong
Regulatory status. Radiesse holds US FDA premarket approval, first granted in December 2006 for facial folds and HIV-associated lipoatrophy. In Singapore, fillers are medical devices regulated by the Health Sciences Authority; the page on how aesthetic medicine is regulated in Singapore explains what can be checked.
Several materials are sold with similar promises, and the differences decide what can be undone and how a complication is managed.
A clinic offering "Radiesse" may also mean either the undiluted or the hyperdiluted procedure, and it is worth asking which.
CaHA is a structural choice, so the assessment is about structure first and product second.
Where laxity rather than support is the real complaint, he says so and points to an energy-based lift instead.
CaHA is the firmest of the three collagen biostimulators Dr Sin Yong uses and the one with the most immediate effect, which is why it is chosen where support rather than diffuse volume is wanted. The Radiesse page covers both forms. In acne scar work it is the filler support step of his 4D Scar Reconstruction, placed beneath a released scar so the floor can rise; the pairing is described on subcision with filler. For nose refinement he usually chooses CaHA or PCL rather than a hyaluronic acid-only product. As with the other non-HA materials, nothing here dissolves, so ultrasound mapping and a conservative plan come first; the wider class is defined under biostimulator.
Both, depending on how it is used. Undiluted, the gel and microspheres fill on the day and collagen forms afterwards; diluted with saline or lidocaine, the volume effect is slight and it is used for skin quality.
Not by hyaluronidase, which acts only on hyaluronic acid. Intralesional sodium thiosulfate has been reported for CaHA nodules; it is a management option, not an equivalent of dissolving.
Kadouch JA. Calcium hydroxylapatite: a review on safety and complications. J Cosmet Dermatol. 2017;16(2):152-161. doi:10.1111/jocd.12326. source
Wollina U, Goldman A. Spontaneous and induced degradation of dermal fillers: a review. J Cutan Aesthet Surg. 2024;17(4):273-281. doi:10.4103/JCAS.JCAS_137_23. source
Radiesse — Premarket Approval P050037. U.S. FDA Premarket Approval database. www.accessdata.fda.gov
Rheological properties of calcium hydroxylapatite and hyaluronic acid fillers. Journal of Drugs in Dermatology (PubMed), 2010. pubmed.ncbi.nlm.nih.gov
Efficacy and Safety of Calcium Hydroxylapatite for Nasal Augmentation: A 12-Month Prospective Study in a Chinese Population. PubMed. pubmed.ncbi.nlm.nih.gov
Foreign Body Granulomas Reaction Related to Collagen Stimulatory Cosmetic Fillers: A Systematic Review. Journal of Cosmetic Dermatology (PubMed). pubmed.ncbi.nlm.nih.gov
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