Glossary · Dr Sin Yong’s protocols

Calcium hydroxylapatite (CaHA):
what the term means

Medically reviewed by Dr Sin Yong · Last reviewed · 3 min read

Published 13 October 2026 · Reviewed by Dr Sin Yong

Abstract still life of glass ampoules and droplets in soft light, illustrative

Calcium hydroxylapatite (CaHA) is a biocompatible mineral, chemically similar to the mineral in bone and teeth, used in aesthetic medicine as microspheres of 25 to 45 µm suspended in a gel carrier. CaHA is the material in Radiesse. Undiluted, it gives volume on the day and stimulates collagen afterwards; diluted, it becomes a skin-quality treatment for the face, neck and body. Hyaluronidase does not dissolve either form.

Key facts
Material
About 30% CaHA microspheres of 25–45 µm in about 70% aqueous gel of sodium carboxymethylcellulose, glycerin and water
Product
Radiesse (Merz); Radiesse (+) adds lidocaine
Two uses
Undiluted for volume and contour; diluted for skin quality on face, neck and body
Dissolvable?
Not by hyaluronidase; intralesional sodium thiosulfate has been reported for CaHA nodules as a management option
A woman in her forties in three-quarter view with soft light on the cheekbone (illustrative image, not a patient)
Illustrative image, not a patient.

Where calcium hydroxylapatite matters on this site

CaHA appears wherever this site discusses support on bone rather than volume in soft tissue. Because the microspheres are firm and cannot be dissolved, every page that uses it pairs it with ultrasound mapping and a conservative first placement.

CaHA is chosen for support on bone; if a plan needs something that can be taken back, it is the wrong material.— Dr Sin Yong

Regulatory status. Radiesse holds US FDA premarket approval, first granted in December 2006 for facial folds and HIV-associated lipoatrophy. In Singapore, fillers are medical devices regulated by the Health Sciences Authority; the page on how aesthetic medicine is regulated in Singapore explains what can be checked.

Not to be confused with

Several materials are sold with similar promises, and the differences decide what can be undone and how a complication is managed.

A clinic offering "Radiesse" may also mean either the undiluted or the hyperdiluted procedure, and it is worth asking which.

What decides whether CaHA matters for you

CaHA is a structural choice, so the assessment is about structure first and product second.

Where laxity rather than support is the real complaint, he says so and points to an energy-based lift instead.

Dr Sin Yong prefers energy-based treatment for almost every concern that injectables are used for: FSX Laser for the skin, and the VF Lift for lifting and hollow areas. It adds no product, so there is no injected material to cause pillow face, migration or lumps. Where an injectable is the right choice, he says so and explains why.
Radiesse lumps, and only offered surgery? Get assessed first: cutting filler out leaves a scar and can cause dents or nerve injury. Find out how Dr Sin Yong treats hard lumps without surgery.

Where it fits

CaHA is the firmest of the three collagen biostimulators Dr Sin Yong uses and the one with the most immediate effect, which is why it is chosen where support rather than diffuse volume is wanted. The Radiesse page covers both forms. In acne scar work it is the filler support step of his 4D Scar Reconstruction, placed beneath a released scar so the floor can rise; the pairing is described on subcision with filler. For nose refinement he usually chooses CaHA or PCL rather than a hyaluronic acid-only product. As with the other non-HA materials, nothing here dissolves, so ultrasound mapping and a conservative plan come first; the wider class is defined under biostimulator.

Frequently Asked Questions

Because it is firmer and holds projection on the bone with less spread, so a small amount placed with a fine needle on the bone can shape the bridge or tip. The trade-off is that hyaluronidase cannot dissolve it. Where a patient wants the option of reversal, a hyaluronic acid product is discussed instead. In either case the nose is treated as a high-risk vascular area, and the plan is made after examination.
The product is the same; the dilution changes the procedure. Undiluted or lightly diluted, it is placed deep and sparingly where structure is needed, such as the chin or jawline. Hyperdiluted, it is spread thinly in the superficial plane across an area such as the neck or the backs of the hands to improve skin quality rather than add volume. They are planned as two separate treatments.

Both, depending on how it is used. Undiluted, the gel and microspheres fill on the day and collagen forms afterwards; diluted with saline or lidocaine, the volume effect is slight and it is used for skin quality.

Not by hyaluronidase, which acts only on hyaluronic acid. Intralesional sodium thiosulfate has been reported for CaHA nodules; it is a management option, not an equivalent of dissolving.

References

Kadouch JA. Calcium hydroxylapatite: a review on safety and complications. J Cosmet Dermatol. 2017;16(2):152-161. doi:10.1111/jocd.12326. source

Wollina U, Goldman A. Spontaneous and induced degradation of dermal fillers: a review. J Cutan Aesthet Surg. 2024;17(4):273-281. doi:10.4103/JCAS.JCAS_137_23. source

Radiesse — Premarket Approval P050037. U.S. FDA Premarket Approval database. www.accessdata.fda.gov

Rheological properties of calcium hydroxylapatite and hyaluronic acid fillers. Journal of Drugs in Dermatology (PubMed), 2010. pubmed.ncbi.nlm.nih.gov

Efficacy and Safety of Calcium Hydroxylapatite for Nasal Augmentation: A 12-Month Prospective Study in a Chinese Population. PubMed. pubmed.ncbi.nlm.nih.gov

Foreign Body Granulomas Reaction Related to Collagen Stimulatory Cosmetic Fillers: A Systematic Review. Journal of Cosmetic Dermatology (PubMed). pubmed.ncbi.nlm.nih.gov

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