Advanced Fillers vs Classic HA
More About Fillers · Dr Sin Yong · Orchard Road, Singapore

Advanced Fillers vs Classic HA

Radiesse and Ellanse vs traditional hyaluronic acid fillers — understanding the key differences in mechanism, longevity, collagen stimulation and the right clinical application for each.

16 July 2021
More About Fillers

Advanced Fillers vs Classic HA

Not all fillers are the same. The filler category encompasses products with very different mechanisms, longevity, reversibility profiles and clinical applications. Understanding these differences is essential for selecting the right product for each patient and each anatomical zone.

Classic HA Fillers

Hyaluronic acid (HA) fillers are the most commonly used dermal fillers globally. They provide immediate volume correction, are reversible with hyaluronidase, and last 9–18 months depending on the product and zone. Classic HA fillers work primarily through physical volume replacement — they do not significantly stimulate collagen production.

Radiesse — Calcium Hydroxylapatite

Radiesse is composed of calcium hydroxylapatite microspheres suspended in a gel carrier. It provides immediate volume and also acts as a biostimulator — the microsphere scaffold stimulates the patient's own collagen production. Results typically last 18–24 months, and Radiesse is particularly effective for structural support (nose, chin, jawline, forehead, hands).

Ellanse — Polycaprolactone

Ellanse uses polycaprolactone (PCL) microspheres, which biostimulate collagen even more substantially than Radiesse. Available in 1, 2, 3 and 4-year formulations, Ellanse provides sustained collagen stimulation long after the initial volume has resolved — making it particularly suitable for patients seeking long-term structural regeneration.

Dr Sin Yong uses Radiesse and Ellanse as his primary filler products for structural zones — nose, chin, forehead, and hands. HA fillers are reserved for zones requiring precision soft-tissue correction (lips, tear troughs) where reversibility is paramount.

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Frequently Asked Questions

What is the difference between Radiesse, Ellanse and HA fillers?+

HA (hyaluronic acid) fillers are soft and reversible. Radiesse (calcium hydroxylapatite) and Ellanse (polycaprolactone) are biostimulators that provide stronger structural support and stimulate collagen, but are not reversible.

Which filler lasts longest?+

Ellanse offers the longest duration (up to several years depending on formulation), Radiesse lasts around 18–24 months, and HA fillers typically last 9–18 months depending on the area.

When is a biostimulator filler preferred over HA?+

Biostimulators like Radiesse and Ellanse are preferred for structural areas such as the chin, jawline and nose where support and collagen stimulation matter. HA is preferred for soft areas like lips and tear troughs.

Are biostimulator fillers reversible?+

No. Unlike HA, Radiesse and Ellanse cannot be dissolved, so correct placement by an experienced doctor is essential.

S
Dr Sin Yong
MBBS (NUS) · MRCS (Edinburgh) · MSc Aesthetic Medicine (London) · MSc Practical Dermatology (Cardiff)
International KOL — CLASSYS · HIRONIC · DEKA · ALMA · FOTONA · LUTRONIC