Medically reviewed by Dr Sin Yong · Last reviewed · 6 min read · Jump to questions
The immune reaction that often sits behind fibrosis: filler granuloma.
Where dissolving has already been tried: hyaluronidase not working.
Main guide Filler complications in Singapore — the kinds of problem, the urgent signs and how Dr Sin Yong assesses them.
Published 13 November 2026 · Reviewed by Dr Sin Yong

A fibrotic filler lump is a firm lump made partly or wholly of scar tissue that the body has laid down around injected filler. It feels harder than the filler did, it does not soften with massage, and dissolving injections alone do not clear it, because they act on hyaluronic acid and not on scar tissue.
Part of Filler lumps and nodules →
Fibrosis is the body’s repair response: it lays down collagen-rich scar tissue. Around injected filler, that tissue can form a firm shell, run through the product, or remain after the product itself has gone. The result is a lump that is harder than filler and does not behave like it.
It is one of several things a hard lump can be. Others are filler collected in one place, a filler granuloma, and an inflamed or infected nodule. They can feel alike under a finger and can exist together in the same lump. The wider picture is on filler lumps and nodules.
Fibrosis follows repeated or prolonged irritation of tissue. With filler, the usual settings are repeated treatment in the same area over years, different products layered on top of each other, a past episode of swelling or infection, and the body walling off material it cannot break down.

In a small ultrasound study of lumps inside the lips after filler, the two cases of marked fibrosis were attributed to repeated filler procedures, including fillers other than hyaluronic acid and earlier attempts to remove filler or treat complications (Skrzypek and Mlosek 2020).
Collagen-stimulating products work by prompting the body to make collagen, so a nodule from those products is a related but separate problem. Those are covered on Sculptra lumps, Ellansé lumps and Juvelook lumps.
The four are managed differently, so telling them apart is the first step.
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| What it is | Typical timing | Does hyaluronidase clear it? | |
|---|---|---|---|
| Lump of filler | The product itself, gathered in one place or placed too near the surface | Usually soon after treatment | Yes, where the product is hyaluronic acid |
| Fibrotic lump | Scar tissue around or in place of the filler | Usually late; often after repeated treatment | No; only any hyaluronic acid still inside it |
| Granuloma | An immune reaction that walls the filler off, often with scar tissue | Usually months to years later | Only where the filler is hyaluronic acid, and often not on its own |
| Inflamed or infected nodule | A red, hot, tender or draining lump | Any time | Not the first step; it is treated medically first |
These are general patterns, not rules, and one lump can contain more than one of them.
By the history, the examination and a scan. In 15 women with lumps where hyaluronic acid filler had been injected, high-frequency ultrasound showed filler deposits in 9, granulomas in 3, fibrosis in 2 and a deposit with inflammation in 1, and the authors reported that each had a typical appearance on the scan (Mlosek 2020).
A scan also shows how deep the lump sits, how far it extends and which vessels run beside it. Where the picture is unclear, or the lump does not look like filler at all, further tests including a tissue sample are arranged. How Dr Sin Yong uses the scan is described under ultrasound-guided filler dissolving.
Hyaluronidase is an enzyme that breaks down hyaluronic acid. It does not act on scar tissue, and it does not act on fillers made of other materials. If a lump is still there after dissolving, the possibilities include hyaluronic acid that the enzyme did not reach, a filler that is not hyaluronic acid, a granuloma, or fibrous tissue.
An international consensus on delayed reactions to hyaluronic acid filler also notes that hyaluronidase can fail on its own, particularly with firmer, more tightly cross-linked gels (Philipp-Dormston 2020). Repeating it without knowing what the lump is made of is not a plan. The causes are set out on hyaluronidase not working.
The same consensus groups late lumps into inflamed and non-inflamed, and describes these steps (Philipp-Dormston 2020):
That guidance was written about hyaluronic acid filler and does not address fibrosis as a separate entity. It is given here as background, not as a treatment plan for any individual.
Urgent: a change in vision or eye pain after an injection means calling 995 now. Skin that turns white, pale, dusky or mottled, or pain that is getting worse, needs the doctor who injected you, or A&E, now.
A lump that becomes red, hot, swollen, tender or starts to drain needs a doctor the same day, or A&E if no doctor can see you. Infection and inflammation are treated medically before anything else is done to the lump.
He does not add more filler to hide a lump. Like any laser, the Sculpting mode can cause blistering or a change in skin colour, so settings are chosen for your skin.
Cutting a lump out leaves a scar and can leave a dent, and removal is often incomplete where the tissue has no clear border. What published series report, both where surgery fell short and where it did well, is set out on filler granuloma. An assessment with a scan first shows what the lump is made of, which is what any decision about surgery should rest on.
Not for emergencies. A change in vision or eye pain after an injection: call 995 now. Pale, dusky or mottled skin, or pain that is getting worse: go now to the doctor who injected you, or to A&E. Do not message or book for these signs.
Every treatment is performed by Dr Sin Yong personally. Singapore Medical Council registered · invited to share his clinical expertise internationally for CLASSYS, DEKA, Fotona, Hironic and Ilooda.
A hard lump is examined and scanned with ultrasound before any treatment is advised. How consultations work.
WhatsApp Dr Sin Yong →or use the enquiry formA fibrotic filler lump is a firm lump made partly or wholly of scar tissue (fibrosis) that the body has formed around or in place of injected filler. It is harder than the filler was and does not soften with massage.
Not by hyaluronidase alone. Hyaluronidase breaks down hyaluronic acid and does not act on scar tissue. Any hyaluronic acid still inside the lump can be dissolved; the fibrous tissue is assessed separately.
A finger cannot tell reliably. History, examination and high-frequency ultrasound help to tell filler deposits, granulomas, fibrosis and inflammation apart. Where the scan is unclear, a tissue sample may be arranged.
Possible reasons are hyaluronic acid the enzyme did not reach, a filler that is not hyaluronic acid, a granuloma, or fibrous tissue. Repeating hyaluronidase without knowing which applies is not advised; a scan comes first.
A stable firm lump that does not hurt is not an emergency. A lump that turns red, hot, swollen, tender or starts to drain needs a doctor the same day. Skin colour change or a change in vision after an injection is an emergency.
Not always. It depends on what the scan shows the lump is made of, its size and depth, and whether it is changing. Surgery leaves a scar and removal can be incomplete, so an assessment with ultrasound comes before that decision.
Mlosek RK, Migda B, Skrzypek E, Słoboda K, Migda M. The use of high-frequency ultrasonography for the diagnosis of palpable nodules after the administration of dermal fillers. Journal of Ultrasonography, 2020. source
Skrzypek E, Mlosek RK. High frequency ultrasound assessment of labial glands simulating small nodules or granulomas after lip augmentation. Journal of Ultrasonography, 2020. source
Philipp-Dormston WG, Goodman GJ, De Boulle K, et al. Global Approaches to the Prevention and Management of Delayed-onset Adverse Reactions with Hyaluronic Acid-based Fillers. Plastic and Reconstructive Surgery Global Open, 2020. source
About this page: written and medically reviewed by Dr Sin Yong, MBBS (NUS), MRCS (Edinburgh) · Last reviewed 13 November 2026 · Illustrative images only, not patients · Editorial policy
Consultations by appointment at 9 Scotts Road, Pacific Plaza #12-01, Singapore 228210.
Not for emergencies. A change in vision or eye pain after filler: call 995 now. Pale, dusky or mottled skin, or pain that is getting worse: go now to the doctor who injected you, or to A&E. Do not message or book for these signs.
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